An inside-out vein graft filled with. platelet-rich plasma for repair of a short sciatic nerve defect in rats |
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| Authors: | Ji Yeong Kim ;Woo Joo Jeon ;Dong Hwee Kim ;Im Joo Rhyu ;Young Hwan Kim ;Inchan Youn ;Jong Woong Park |
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| Institution: | [1]Department of Orthopedic Surgery, Seoul Paik Hospital, Inje University, Seoul, Korea; [2]Department of Orthopedic surgery, Korea University, Seoui, Korea; [3]Department of Physical Medicine & Rehabilitation, Korea University, Seoul, Korea; [4]Department of Anatomy, Korea University, Seoul, Korea; [5]Biomedical Research Center, Korea Institute of Science and Technology, Seoul, Korea |
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| Abstract: | Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects. |
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| Keywords: | nerve regeneration peripheral nerve injury sciatic nerve platelet-rich plasma in-side-out vein autografi myelinated axons axon diameter myelin sheath thickness histology sciaticnerve index neural regeneration |
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