| 诱导多潜能干细胞技术研究进展及临床应用前景 |
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| 引用本文： | 冯 睡,安广宇,尹金淑. 诱导多潜能干细胞技术研究进展及临床应用前景[J]. 医学综述, 2014, 0(13): 2312-2314 |
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| 作者姓名： | 冯 睡 安广宇 尹金淑 |
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| 作者单位： | [1]北京大学第九临床学院,北京100038; [2]首都医科大学附属北京朝阳医院肿瘤科,北京100020; [3]首都医科大学附属北京世纪坛医院耳鼻咽喉科,北京100038 |
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| 基金项目： | 北京市教育委员会2012年科技发展计划项目（SQKM201210025025） |
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| 摘 要： | 成熟体细胞能被重编程为诱导多潜能干细胞,这种干细胞具有分化全能性、体外易扩增、易于基因干扰或过表达等特性。随着诱导多潜能干细胞项技术在技术路线上的不断改进,以及其在细胞来源和分化方面的突破,该技术在再生医学、药物研发评价、组织工程等领域有着越来越广泛的应用前景。
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| 关 键 词： | 诱导多潜能干细胞 再生医学 细胞治疗 疾病模型 |
Research Progress and Clinical Application Prospect of Induced Pluripotent Stem Cell Technology |
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| Affiliation: | FENG Shui ,AN Guaag-ya, YIN Jin-shu (1. The Ninth Clinical College of Peking University, Beijing 100038, China; 2. Department of Oncology , Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China; 3. Department of Otorhinolaryngology, Beijing Shijitan Hospital Affiliated to Capital Medical University ,Beijing 100038 ,China) |
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| Abstract: | Somatic cells can be reprogramed and generated induced pluripotent stem cells（iPSC）,which is a kind of stem cells with the properties of totipotency,convenience in vitro amplification and gene interference or gene overexpression.With the improvements in iPSC technology and breakthroughs in cell sources and cell differentiation,this technology is holding up more and more extensive application foregrounds in regenerative medicine,drug evaluation and tissue engineering. |
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| Keywords: | Induced pluripotent stem cell Regenerative medicine Cell therapy Disease model |
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