小鼠静脉注射邻苯二甲酸丁基苄酯的毒物动力学

目的　研究氚标记的环境激素邻苯二甲酸丁基苄酯 (BBP)单次静脉注射后在其雄、雌小鼠体内的动力学过程的差异。方法　雄、雌小鼠各 3 0只 ,每组性别小鼠分 3组 ,每组 10只。静脉注射 10和 10 0mg kg3H -BBP后 ,用液闪仪检测给予一定时间后 ,检测在血清及各脏器中的放射性浓度 ,用NDST2 1药代动力学处理软件判断房室模型 ,计算各种参数。结果　3H- BBP单次静脉注射后在小鼠体内呈一级动力学线性过程 ,符合二室开放模型 ,3H- BBP在雄性小鼠的组织脏器内被大量摄取 ,以肝脏及性腺居高 ,蓄积性明显高于雌性。3H- BBP主要经尿排泄 ,并集中在 8h之内排泄 ,4d之内排泄量占注入量的 80 %左右。结论　静脉注射3H -BBP在雌、雄小鼠体内的动力学过程有明显的差异。

The toxicity pharmacokinetics of butylbenzyl phthalate by injection of vein in mice

Objective To study on the toxicity pharmacokinetics of butylbenzyl phthalate(BBP)with 3H in mice after a single injection of vein.Methods After g iven 10 mg/kg and 100 mg/kg 3H-BBP for a certain interval,radialized conc entrations in blood serum and organs were detected by multi-purpose scintillati on counter.Pharmacokinetic compartment model was evaluated by NDST21 software,an d parameters were calculated.Results First-order linear equati on and two-compartment open model were gained.3H-BBP was largely absorbed by male mice especially by liver and gonad,and the cumulative amounts of male mice were larger than female.Generally 3H-BBP was mainly excreted by urine wit hin 8 hours,and 80% of 3H-BBP was excreted within 4 days.Conclusion The pharmacokinetic processes of 3H-BBP by injection of vein were different between male and female in vivo.