286株葡萄球菌的耐药性分析

目的]了解葡萄球菌在临床上的分布及对常用抗菌药物的耐药性，为临床选择抗菌药物提供依据。方法]用VITEK32型全自动细菌分析系统对我院临床分离的286株葡萄球菌进行鉴定，药敏试验采用K—B法，割断标准按NCCLS2002年版进行。结果]共分离出葡萄球菌286株，其中金黄色葡萄球菌66株，耐甲氧西林金黄色葡萄球菌（MRSA）21株，占31．8％，凝固酶阴性葡萄球菌220株，耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）186株，占84．5％：MRSA和MRCNS除对万古霉素和替考拉宁的耐药率为0％外．对其他大多数抗菌药物的耐药率均较高，甲氧西林敏感葡萄球菌（MSS）除对青霉素、氨苄西林、克拉霉素和红霉索等的耐药率（51．1％～88．9％）较高外，对其他抗营药物的耐药率较低。结论]该院葡萄球菌的耐药率有逐渐增高趋势，临床医师应根据药敏结果选择抗茵药物。

THE DRUG TOLERANCE ANALYSIS OF 286 STRAINS STAPHYLOCOCCUS

Objective]To understand the distribution of staphylococcus and it's drug resistance in antimicrobial drugs,to provide clinical referance for drug selection.Methods]286 strains staphylococcus were identified by 32 type VITEK in our affiliated hospital,susceptibility test was performed by(K-B)method,with the distinguishing standard according to NCCLS 2002.Results]286 strains staphylococcus were separated.Among them,there were 66 strains staphylococcus aureus,21 strains of which were meticillin-resistant staphylococcus(MRSA)and accounted for 31.8%,Coagulase-negative were 220 strains staphylococeus,186 strains of which were meticillin-resistant coagurase-negative staphylococcus and accounted for 84.5%;MRSA and MRCNS in drug tolerance rate were high to most of antimicrobial agents except Vancomycin and Teicoplanin.The resistance rate of MSS to Penicillin,Ampicillin,Clarithromycin and Erythromycin were high(51.1%-88.9%),while that to the rest antimicrobial agents were low.Conclusions]The drug tolerance rate of staphylococous increases gradually,physicians should select antibiotic drugs according to drug sensitivity.