Cross-linked amylose tablets containing α-amylase: an enzymatically-controlled drug release system |
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Authors: | Yves Dumoulin Louis H Cartilier Mircea A Mateescu |
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Abstract: | An oral controlled release system based on direct compression of cross-linked amylose (CLA) and drug powders was previously introduced. For drugs with limited solubility or for some drugs for which solubility can be influenced by variation of gastro–intestinal pH, a system is required to accelerate drug release. This paper describes a novel enzymatically-controlled drug release (ECDR) system based on the addition of α-amylase to CLA tablets, which can modulate the release kinetics of drugs. The α-amylase within the tablets is able to hydrolyze α-1-4-glucosidic bonds present in the CLA semisynthetic substrate. Increasing amounts of α-amylase (5 to 25 EU) within the tablets induced a significant decrease in release time from 24 to 6 h. High amounts of external α-amylase (300–6000 EU/l) had a slight effect on the release rate. Drug release from the ECDR system seems to be controlled by two sequential mechanisms: (a) hydration and swelling of CLA tablets followed by (b) internal enzymatic hydrolysis of the hydrated gel phase. |
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Keywords: | drug delivery system amylose amylase |
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