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Catalase determination in various etiologic forms of Wilms' tumor and gonadoblastoma |
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| Authors: | C Junien C Turleau G M Lenoir T Philip R Said S Despoisse C Laurent M O Rethoré J C Kaplan J de Grouchy |
| Institution: | 1. Institut de Pathologie Moléculaire, INSERM U.129, Paris, France;2. Cytogénétique Humaine et Comparée, ER.149 CNRS, INSERM U.173, Paris, France;3. Institut de Progénèse, Paris, France;4. International Agency of Research on Cancer, Lyon, France;5. Centre Léon Bérard, Lyon, France;6. Service de Cytogénétique, Institut Pasteur de Lyon, Lyon, France |
| Abstract: | We have previously mapped the gene coding for catalase to 11p13 by gene dosage analysis. Deletion of this chromosomal region causes aniridia, mental retardation, and predisposition to Wilms' tumor (WT). In the present study, 22 patients with various etiologic forms of WT and/or aniridia were investigated. The catalase (CAT) level and karyotype were examined in order to determine the linkage and the gene ordering on chromosome number 11 of the different loci involved. The CAT concentration was normal in the 19 cases without detectable chromosomal abnormalities. |
| Keywords: | Address requests for reprints to Dr C Junien Institut de Pathologie Moléculaire U 129 INSERM CHU COCHIN 24 Rue du Fg St Jacques 75674 Paris Cedex 14 France |
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