甘草叶中黄酮类成分的化学研究

自甘草(Glycyrrhiza uralensis Fisch)的叶中分离到四个黄酮类化合物。根据理化性质,光谱(UV,MS,¹HNMR)数据分析,分别确定结构为3,5,7,3′,4′-五羟基-5′-异戊烯基黄酮(Ⅰ),3,6,7,3′,4′-五羟基-2′-异戊烯基黄酮(Ⅱ),5,7,3′,4′-四羟基-5′-异戊烯基二氢黄酮(Ⅲ)和槲皮素-3,3′-二甲醚(Ⅳ)。其中,Ⅰ,Ⅱ和Ⅲ是新化合物,分别命名为乌拉尔醇(uralenol),新乌拉尔醇(neouralenol)和乌拉尔宁(uralenin)。Ⅳ在本属植物中为首次发现。Ⅲ为甘草叶中的主要黄酮类成分。本文解释了B环某些裂解碎片丰度与异戊烯基和氧取代基相对位置的关系。

STUDIES ON FLAVONOID CONSTITUENTS ISOLATED FROM THE LEAVES OF GLYCYRRHIZA URALENSIS FISCH

Four flavonoids were isolated from the alcoholic extract of the leaves of Glycyrrhiza uralensis Fisch. (Leguminosae). On the basis of physicochemical properties and spectroscopic analysis their structures were elucidated as 3,5,7,3',4'-pentahydroxy-5'-isoprenylflavone(I), 3,6,7,3',4'-pentahydroxy-2'-isoprenylflavone(II) and 5,7,3',4'-tetrahydroxy-5'-isoprenyl-flavonone(III) and quercetin-3,3'-dimethylether(IV). Compounds I, II and III are new compounds and named uralenol, neouralenol and uralenin respectively. Compound IV was found in this genus for the first time. Compound III was shown to be the major constituent in the leaves of Glycyrrhiza uralensis Fishch.