| 若干莽草酸衍生物的合成和生物活性研究 |
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| 引用本文： | 孙快麟,李润荪,雷兴翰. 若干莽草酸衍生物的合成和生物活性研究[J]. 药学学报, 1990, 25(1): 73-76 |
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| 作者姓名： | 孙快麟 李润荪 雷兴翰 |
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| 作者单位： | 上海医药工业研究院，上海医药工业研究院，上海医药工业研究院 上海 200040，上海 200040，上海 200040 |
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| 摘 要： | 虽然对莽草酸(shikimic acid)的研究由来已久,但只是在陆续发现了具有生物活性的乙二醛酶Ⅰ抑制剂(glyoxalase Ⅰinhibitor 1)和二(口恶)霉素(dioxolamycin 2)等含莽草酸类母核的天然产物后,才有合成莽草酸衍生物进行生物活性研究的报道,即由莽草酸甲酯合成乙二醛酶Ⅰ抑制剂的类似物3。
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| 关 键 词： | 莽草酸衍生物 二噁霉素 |
| 收稿时间： | 1988-11-14 |
STUDIES ON THE SYNTHESIS AND BIOACTIVITY OF SOME NEW SHIKIMIC ACID DERIVATIVES |
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| KL Sun,RS Li and XH Lei. STUDIES ON THE SYNTHESIS AND BIOACTIVITY OF SOME NEW SHIKIMIC ACID DERIVATIVES[J]. Acta pharmaceutica Sinica, 1990, 25(1): 73-76 |
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| Authors: | KL Sun RS Li XH Lei |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry. |
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| Abstract: | Ten new shikimic acid derivatives, some of which are analogs of dioxolamycin were synthesized from methyl shikimate because the bioactivity of shikimic acid derivatives has received considerably less attention to date. Compounds 4-10, 12, 16 were subjected to antimicrobial test in vitro, and showed no activity (MIC greater than 25 micrograms/ml). Compounds 4-10, 12, 13, and 16 were subjected to cytostatic activity test against cultured L 1210 Leukemia cells in vitro. Compounds 4, 6, 13 and 16 showed cytostatic activity like dioxolamycin. |
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| Keywords: | Shikimic acid derivatives Dioxolamycin |
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