| 抗肿瘤药物的研究:N′,N″-二螺三哌嗪类化合物的合成 |
| |
| 引用本文： | 陈恒昌,刘振中,李润涛.抗肿瘤药物的研究:N′,N″-二螺三哌嗪类化合物的合成[J].药学学报,1990,25(10):785-789. |
| |
| 作者姓名： | 陈恒昌 刘振中 李润涛 |
| |
| 作者单位： | 郑州大学化学系,郑州450052;*硕士研究生 |
| |
| 摘 要： | In order to search for new antitumor drugs, sixteen N′, N″-dispirotripiperazine derivatives were synthesized from N′, N″-dispirotripiperazinium dichloride dihydrochloride by substitution, acylation and Mannich reaction. Six compounds were selected for preliminary pharmacological test. The result showed that five compounds possess inhibitory action against carcinoma S37 in rats. The inhibitory activity of compounds Ⅵ and Ⅹ was 55.0% and. 41.9% respectively.
|
| 关 键 词： | 抗肿瘤药 N′ N″-二螺三哌嗪 |
| 收稿时间： | 1989-07-06 |
Studies on antitumor drugs: the synthesis of N',N"-dispirotripiperaziniums |
| |
| HC Chen,ZZ Liu and RT Li.Studies on antitumor drugs: the synthesis of N',N"-dispirotripiperaziniums[J].Acta Pharmaceutica Sinica,1990,25(10):785-789. |
| |
| Authors: | HC Chen ZZ Liu and RT Li |
| |
| Institution: | Department of Chemistry, Zhengzhou University. |
| |
| Abstract: | In order to search for new antitumor drugs, sixteen N',N"-dispirotripiperazine derivatives were synthesized from N',N"-dispirotripiperazinium dichloride dihydrochloride by substitution, acylation and Mannich reaction. Six compounds were selected for preliminary pharmacological test. The result showed that five compounds possess inhibitory action against carcinoma S37 in rats. The inhibitory activity of compounds VI and X was 55.0% and 41.9% respectively. |
| |
| Keywords: | N' N" -Dispirotripiperazine Antitumor drugs |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
| 点击此处可从《药学学报》下载免费的PDF全文 |
|
