| 青蒿琥酯经皮肤吸收治疗猴疟的疗效 |
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| 引用本文： | 宣文漪,赵一,李爱嫒,谢沛珊,刘旭. 青蒿琥酯经皮肤吸收治疗猴疟的疗效[J]. 药学学报, 1990, 25(3): 220-222 |
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| 作者姓名： | 宣文漪 赵一 李爱嫒 谢沛珊 刘旭 |
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| 作者单位： | 广西中医学院，广西中医学院，广西中医学院，广西中医学院，广西桂林制药厂 南宁 530001，南宁 530001，南宁 530001，南宁 530001，桂林 541002 |
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| 摘 要： | 青蒿琥酯为高效、速效、低毒的抗疟新药,但近期复燃率较高。为了提高疗效,方便使用,乃研究其经皮肤吸收制剂。青蒿琥酯经皮肤吸收对鼠疟的疗效,在小鼠及兔体内的药代动力学研究已取得较好的结果,现报告对猴疟的疗效。
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| 关 键 词： | 抗疟药 青蒿琥酯 皮肤吸收剂 猴疟 |
| 收稿时间： | 1989-02-17 |
EFFECT OF ARTESUNATE TRANSDERMAL PREPARATION ON PLASMODIUM CYNOMOLGI |
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| WY Xuan,Y Zhao,AY Li,PS Xie and X Liu. EFFECT OF ARTESUNATE TRANSDERMAL PREPARATION ON PLASMODIUM CYNOMOLGI[J]. Acta pharmaceutica Sinica, 1990, 25(3): 220-222 |
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| Authors: | WY Xuan Y Zhao AY Li PS Xie X Liu |
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| Affiliation: | Guangxi College of Traditional Chinese Medicine, Nanning. |
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| Abstract: | Artesunate transdermal preparation at 5, 10, or 15 mg/kg, bid, for 3 days applied locally on the shaved skin of the back of monkeys showed reliable therapeutic effects on Plasmodium cynomolgi, but recrudescence of the parasites was not controlled. If some azone was added in the artesunate transdermal preparation at the dosage of 5 mg/kg, bid, for 3 days, the parasitemia of plasmodium cynomolgi could be cleared and recrudescence prevented, thus, the antimalarial effects was enhanced. |
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| Keywords: | Antimalarials Artesunate Transdermal preparation plasmodium cynomolgi |
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