| 甾体不对称合成的研究——ⅩⅥ.dl-3-氧杂-A-失碳甾体化合物的合成 |
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| 引用本文： | 魏国平,周维善. 甾体不对称合成的研究——ⅩⅥ.dl-3-氧杂-A-失碳甾体化合物的合成[J]. 药学学报, 1990, 25(1): 69-72 |
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| 作者姓名： | 魏国平 周维善 |
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| 作者单位： | 中国科学院上海有机化学研究所,上海200032;*中国科学院上海药物研究所 |
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| 摘 要： |
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| 关 键 词： | 呋喃基二噻烷 二酮砜 A-失碳甾体 |
| 收稿时间： | 1989-11-01 |
Study on asymmetric synthesis of steroids. XVI. Synthesis of dl-3-oxa-A-nor steroid |
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| GP Wei and WS Zhou. Study on asymmetric synthesis of steroids. XVI. Synthesis of dl-3-oxa-A-nor steroid[J]. Acta pharmaceutica Sinica, 1990, 25(1): 69-72 |
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| Authors: | GP Wei and WS Zhou |
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| Affiliation: | Shanghai Institute of Organic Chemistry, Academia Sinica. |
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| Abstract: | A synthesis of racemic 3-oxa-A-nor steroid, 8, is reported. The conjugated addition of anion 5 of 5'-methylfuryl dithiane with 4, an intermediate formed from the racemic dionesulfone 3 afforded 6, which was converted to 7 by cyclization under acidic condition. Desulfurization of 7 with tri-n-bu-tyltin hydride gave the title compound 8, which is an intermediate of the target molecule 1b. |
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| Keywords: | Dionesulfone A-nor steroid Furyldithiane |
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