| WB852-β环糊精包合物的研究 |
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| 引用本文： | 王思玲,苏德森,计志忠. WB852-β环糊精包合物的研究[J]. 药学学报, 1990, 25(6): 477-480 |
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| 作者姓名： | 王思玲 苏德森 计志忠 |
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| 作者单位： | 沈阳药学院，沈阳药学院，沈阳药学院 沈阳 110015，沈阳 110015，沈阳 110015 |
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| 摘 要： | 环糊精(cyclodextrin,CD)的发现已近百年,其基础和应用方面的研究至今仍相当活跃,由于环糊精优良的理化性质和生物学特性,可使不稳定的药物包含于环糊精分子内,因此在某种程度上切断药物分子与周围化学环境的联系,而提高药物的稳定性。本文就抗癌抗炎新药WB_(852)~((2,3))的环糊精包合物进行研究,以期提高其化学稳定性。
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| 关 键 词： | WB852 β-环糊精 包合物 |
| 收稿时间： | 1989-05-19 |
A study of the inclusion complex of WB852 with beta-cyclodextrin |
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| SLWang,DS Suand ZZ Ji. A study of the inclusion complex of WB852 with beta-cyclodextrin[J]. Acta pharmaceutica Sinica, 1990, 25(6): 477-480 |
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| Authors: | SLWang DS Suand ZZ Ji |
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| Affiliation: | Shenyang College of Pharmacy. |
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| Abstract: | The aim of this study was to increase the stability of WB852 in aqueous solution by inclusion complex formation with beta-cyclodextrin (beta-CD). The stability of WB852-beta-CD in aqueous solution was determined. The hydrolysis rate of WB852 from the inclusion compound was lower than that of WB852 alone. The solid inclusion compound of WB852 with beta-CD in 1:3 molar ratio was prepared by the freeze-drying method. The formation of an inclusion compound with beta-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential thermal analysis (DTA). |
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| Keywords: | Inclusion compound WB852, β- Cyclodextrin |
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