| 阿托品流通传感器的研制及其在流动注射分析中的应用 |
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| 引用本文： | 刘万忠,伍佩真,晏哲,杨纯华,李安娟,许汝正.阿托品流通传感器的研制及其在流动注射分析中的应用[J].药学学报,1990,25(6):451-456. |
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| 作者姓名： | 刘万忠 伍佩真 晏哲 杨纯华 李安娟 许汝正 |
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| 作者单位： | 湖北省药品检验所，湖北省药品检验所，湖北省药品检验所，湖北省药品检验所，湖北省药品检验所，湖北省药品检验所 武汉 430064，武汉 430064，武汉 430064，武汉 430064，武汉 430064，武汉 430064 |
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| 摘 要： | 本文报道了一种新型的传感器——阿托品流通传感器及其在流动注射分析中的应用。采用流动注射分析法测定了硫酸阿托品片剂和注射剂、盐酸山莨菪碱注射剂、氢溴酸东莨菪碱注射剂及颠茄酊、颠茄片和复方颠茄片的含量,并对硫酸阿托品片和颠茄片含量均匀度进行了测试,方法简便、快速,样品分析速度可达每小时60～100次。
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| 关 键 词： | 阿托品 山莨菪碱 东莨菪碱 颠茄 流通传感器 流动注射分析 |
| 收稿时间： | 1989-04-14 |
CONSTRUCTION AND APPLICATION OF ATROPINE FLOW-THROUGH SENSOR IN FLOW INJECTION ANALYSIS |
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| WZ Liu,PZ Wu,Z Yan,CH Yang,AJ Li and RZ Xu.CONSTRUCTION AND APPLICATION OF ATROPINE FLOW-THROUGH SENSOR IN FLOW INJECTION ANALYSIS[J].Acta Pharmaceutica Sinica,1990,25(6):451-456. |
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| Authors: | WZ Liu PZ Wu Z Yan CH Yang AJ Li and RZ Xu |
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| Institution: | Hubei Provincial Institute for Drug Control, Wuhan. |
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| Abstract: | A new kind of flow-through sensor for atropine has been studied. It exhibits Nernstian response for atropine with a slope of 54 +/- 1 mV/decade over the concentration range of 0.02-200 mmol/L at pH 5-8. The sensitivity coefficients of common compounds were determined. Only bromo-geramine, clonidine, strychnine and amantadine showed remarkable interference. Direct potentiometry for determination of atropine showed an average recovery of 99.2% and a relative standard deviation of 1.3%. It has been used in flow injection analysis (FIA) of atropine, anisodamine and scopolamine and belladonna preparations. Rate of analysis of as high as 60-100 samples/h was achieved. |
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| Keywords: | Atropine Anisodamine Scopolamine Belladonna Flow-through sensor Flow injection analysis |
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