| N2-芳基三嗪青霉素和N2-苯基-N4-烷基(芳基)三嗪青霉素的合成及其抗菌活性 |
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| 引用本文： | 赵临襄,姚庆祥.N2-芳基三嗪青霉素和N2-苯基-N4-烷基(芳基)三嗪青霉素的合成及其抗菌活性[J].药学学报,1990,25(10):739-744. |
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| 作者姓名： | 赵临襄 姚庆祥 |
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| 作者单位： | 沈阳药学院,沈阳110015 |
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| 摘 要： | 设计合成了十个N2-芳基三嗪青霉素和六个N2-苯基-N4-烷基(芳基)三嗪青霉素,这十六个化合物均为未见文献报道的新化合物,元素分析数据和光谱数据证实了它们的结构。初步体外抑菌试验表明,十六个化合物对G(+)菌和G(-)菌均有一定的活性,其中的五个化合物具有一定程度的广谱特征。
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| 关 键 词： | N2-芳基三嗪青霉素 N2-苯基-N4-烷基(芳基)三嗪青霉素 抑荫活性 |
| 收稿时间： | 1989-08-10 |
SYNTHESIS OF N2-ARYL - TRIAZINOYLAMOXICILLINS AND N2-PHENYL - N4- ALKYL ( ARYL )- TRIAZINOYLAMOXICILLINS AND THEIR ANTIBACTEBIAL ACTIVITY |
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| LX Zhao and QX Yao.SYNTHESIS OF N2-ARYL - TRIAZINOYLAMOXICILLINS AND N2-PHENYL - N4- ALKYL ( ARYL )- TRIAZINOYLAMOXICILLINS AND THEIR ANTIBACTEBIAL ACTIVITY[J].Acta Pharmaceutica Sinica,1990,25(10):739-744. |
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| Authors: | LX Zhao and QX Yao |
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| Institution: | Shenyang College of Pharmacy. |
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| Abstract: | Sixteen derivatives of BL-P1908 were synthesized by reaction of 2-aryl-1, 2, 4-triazine -3, 5-dione -6-carboxylic acid, or 2-phenyl-4-alkyl (aryl) -1, 2, 4-triazine-3, 5-dione-6-carboxylic acid with amoxicillin. All of them are new compounds. Their chemical structures were determined by elemental analysis, IR and 1HNMR. Preliminary tests showed that all compounds have marked activities against standard G(+) and G(-) bacteria and five of them have certain characteristic of broad spectrum, but they have no activities against resistant strains S. aureus S1, E coli C1 and P. aeruginosa PS1 isolated from clinic. |
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| Keywords: | N2-Phenyl-N4-alkyl (aryl)-triazinoylamoxicillins Antibacterial activity N2-Aryl-triazinoylamoxicillins |
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