| 莨菪类药物对大鼠胃粘膜损伤的影响 |
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| 引用本文： | 张建福,阎长栋,张亚强,高维忠,翟新民.莨菪类药物对大鼠胃粘膜损伤的影响[J].药学学报,1990,25(2):90-94. |
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| 作者姓名： | 张建福 阎长栋 张亚强 高维忠 翟新民 |
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| 作者单位： | 徐州医学院生理教研室，徐州医学院生理教研室，徐州医学院生理教研室，徐州医学院核医学教研室，徐州医学院核医学教研室 徐州卫校，徐州 221002，徐州 221002 |
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| 摘 要： | 本文观察了莨菪类药物(东茛菪碱、樟柳碱、山茛菪碱)对大鼠三种实验性胃溃疡的影响,并对其作用机制进行了初步的探讨。结果表明:莨菪类药物有对抗大鼠应激性胃溃疡、药物性胃溃疡及慢性胃溃疡的作用,且有量效依赖关系;对胃液和血液等各项生化指标分析表明,这类药物有抑制胃酸分泌、降低胃蛋白酶活性、增强胃粘液屏障,提高血清胃泌素浓度的作用。提示这些结果可能与其抗溃疡效应有关。
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| 关 键 词： | 莨菪类药物 抗溃疡药 胃溃疡 |
| 收稿时间： | 1989-02-22 |
EFFECT OF SCOPOLIA DRUGS ON THE GASTRIC MUCOSAL LESION IN RATS |
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| JF Zhang,CD Yan,YQ Zhang,WZ Gao and XM Zhai.EFFECT OF SCOPOLIA DRUGS ON THE GASTRIC MUCOSAL LESION IN RATS[J].Acta Pharmaceutica Sinica,1990,25(2):90-94. |
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| Authors: | JF Zhang CD Yan YQ Zhang WZ Gao and XM Zhai |
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| Affiliation: | Department of Physiology, Xuzhou Medical College. |
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| Abstract: | In the present paper, effects of scopolia drugs(scopolamine, anisodine, anisodamine) on experimental gastric mucosal lesion models inrats were investigated.
Scopolia drugs were found to be effective anti-ulcer agents in three experimental gastric ulcer models (i.e.cold-restraint stress induced ulcer, indomethacin induced ulcer and acetic acid induced chronic ulcer) in rats in a dose dependent manner.
Biochemical analysis of gastric juice and blood showed that scopolia drugs could inhibit gastric acid secretion and pepsin activity, increase gastric barrier mucus and concentration of serum gastrin, suggesting that these actions may contribute to its anti-ulcer effect. |
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| Keywords: | Scopolia drug Antiulcer agent Gastric ulcer |
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