| 沉香螺环化合物的研究:10-甲基-螺[4.5]-癸-6-烯-6-羧酸的合成 |
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| 引用本文： | 郑完俊,陈淑凤. 沉香螺环化合物的研究:10-甲基-螺[4.5]-癸-6-烯-6-羧酸的合成[J]. 药学学报, 1990, 25(8): 584-589 |
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| 作者姓名： | 郑完俊 陈淑凤 |
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| 作者单位： | 中国医学科学院药物研究所,北京100050 |
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| 摘 要： | 3-甲基△2环已烯-1-酮(4)与1,4-二溴丁烷在氨钠,液氨中或在叔丁醇钾的苯溶液中进行螺环化反应,得到螺环化合物5a+5b以及双螺环化合物6a+6b。经定量催化氢化;羰基与三甲基硅氰加成反应;硅醚水解;脱水和腈基水解,合成了10-甲基-螺[4.5]-癸-6-烯-6-羧酸(11)。药理试验表明该化合物有一定的麻醉催眠作用。
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| 关 键 词： | 螺环化合物 白木香酸 岩兰烷类 |
| 收稿时间： | 1989-04-14 |
STUDIES ON THE SPIROCOMPOUNDS: SYNTHESIS OF 10-METHYL SPIRO [4.5] DEC-6-EN-6-CARBOXYLIC ACID |
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| WJ Zheng and SF Chen. STUDIES ON THE SPIROCOMPOUNDS: SYNTHESIS OF 10-METHYL SPIRO [4.5] DEC-6-EN-6-CARBOXYLIC ACID[J]. Acta pharmaceutica Sinica, 1990, 25(8): 584-589 |
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| Authors: | WJ Zheng and SF Chen |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | 3-Methyl-cyclohexenone 4 spiroannulates with 1, 4-dibromobutane in NaNH2/NH3 or t-BuOK/benzene to afford not only the main monospiro compounds 5a and 5b but also the dispiro compounds 6a and 6b. The title compound 11 was synthesized from 5 through the following steps: Catalytic hydrogenation of the spiro olefinic compounds, addition of trimethylsilycyanide to the carbonyl group, hydrolysis of the siloxyl ether, dehydration of the cyanohydrin and hydrolysis of the cyano group. |
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| Keywords: | Baimuxinic acid Vetivanes Spirocompound |
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