| 苦参碱的正性肌力作用及与细胞外钙的关系 |
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| 引用本文： | 张莎莎,李志红,刘世芳.苦参碱的正性肌力作用及与细胞外钙的关系[J].药学学报,1990,25(8):638-640. |
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| 作者姓名： | 张莎莎 李志红 刘世芳 |
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| 作者单位： | 内蒙古医学院药理教研室，内蒙古医学院药理教研室，内蒙古医学院药理教研室 呼和浩特 010059，呼和浩特 010059，呼和浩特 010059 |
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| 摘 要： | 苦参碱(matrine,Ma)来源于苦豆子Sophora alopecuroides L.)。Ma有加强豚鼠乳头肌收缩的作用,对豚鼠心房亦有明显正性肌力作用。本文对Ma的正性肌力作用与细胞外钙的关系进行了研究。Ma (mp 75.5～77.5℃)为淡黄色粉末结晶,为宁夏盐池制药厂产品。
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| 关 键 词： | 苦参碱 正性肌力作用 |
| 收稿时间： | 1989-07-26 |
RELATIONSHIP BETWEEN THE POSITIVE INOTROPIC ACTION OF MATRINE AND EXTRACELLULAR CALCIUM |
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| SS Zhang,ZH Li and SF Liu.RELATIONSHIP BETWEEN THE POSITIVE INOTROPIC ACTION OF MATRINE AND EXTRACELLULAR CALCIUM[J].Acta Pharmaceutica Sinica,1990,25(8):638-640. |
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| Authors: | SS Zhang ZH Li and SF Liu |
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| Institution: | Department of Pharmacology, Neimenggu Medical College, Huhehaote. |
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| Abstract: | Matrine (Ma) was extracted from the seed and leaves of Sophora alopecuroides L. Ma showed positive inotropic actions in isolated guinea pig left atrium and rat vas deferens under electric stimulation. The positive inotropic actions were markedly inhibited by verapamil (1 mumol/L). Isolated rat vas deferens under the action of Ma showed rhythmic contraction. High K+ (KCl 40 mmol/L) augmented the frequency of rhythmic contraction induced by Ma; conversely, Ma may also augment the increased tension produced by high K+. These results suggest that, the positive inotropic actions of Ma is relevant to its activation of Ca2+ channels. |
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| Keywords: | Matrine Positive inotropic action |
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