| 缩氨基硫脲及其过渡金属络合物的合成与抗菌活性 |
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| 引用本文： | 李迎春,徐丽君.缩氨基硫脲及其过渡金属络合物的合成与抗菌活性[J].药学学报,1990,25(8):593-597. |
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| 作者姓名： | 李迎春 徐丽君 |
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| 作者单位： | 山东医科大学药学系，山东医科大学药学系 济南 250012，济南 250012 |
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| 摘 要： | 本文设计合成了8种缩氨基硫脲化合物及其12种过渡金属络合物,并进行了抑菌实验。结果表明:芳醛(酮)的邻位存在杂原子或取代基团为其缩氨基硫脲活性表现必不可少的结构因素。络合物的抑菌活性一般较缩氨基硫脲本身高,二者遵循不同的抑菌机制。
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| 关 键 词： | 缩氨基硫脲 过渡金属络合物 抑菌活性 |
| 收稿时间： | 1989-07-06 |
SYNTHESIS AND BACTERIOSTATIC ACTIVITY OF THIOSEMICARBAZONE AND THEIR TRANSITION METAL COMPLEXES |
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| YC Li and LJ Xu.SYNTHESIS AND BACTERIOSTATIC ACTIVITY OF THIOSEMICARBAZONE AND THEIR TRANSITION METAL COMPLEXES[J].Acta Pharmaceutica Sinica,1990,25(8):593-597. |
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| Authors: | YC Li and LJ Xu |
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| Institution: | Department of Pharmacy, Shandong Medical University, Jinan. |
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| Abstract: | In this paper, 8 thiosemicarbazones and 12 transition metal complexes thereof have been synthesized and tested for bacteriostatic activity against five kinds of bacteria. The results show that hetero atom or substitution group in the o-position of the aryl ring to the carbonyl group in the aldehyde or ketone is essential to the bacteriostatic activity of the thiosemicarbazones, and different mechanisms of inhibition are followed by thiosemicarbazones and their complexes. The complexes displayed activity superior to the thiosemicarbazones. |
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| Keywords: | Thiosemicarbazones Transition metal complexes Bacteriostatic activity |
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