玻碳电极吸附伏安法测定泰尔登

泰尔登,化学名2-氯-N,N-二甲基噻吨-△~9丙胺,为噻吨类抗精神病药物的主要品种,临床治疗精神分裂症,效果较好,但有关该药物的分析报道甚少。本文首次提出了泰尔登的电化学分析方法——玻碳电极吸附伏安法。作者曾用碳糊电极测定了吩噻嗪类药物,但用该电极测定泰尔登时,却因不能有效富集而未获成功。实验中发现,泰尔登在玻碳表面有强烈的吸附作用,并能在电极上发生氧化反应,溶出峰电流和浓度呈线性关系。本文

ADSORPTIVE STRIPPING VOLTAMMETRY OF CHLORPROTHIXENE AT GLASSY CARBON ELECTRODE

A new electrochemical stripping method for measuring the antipsychotic drug chlorprothixene was reported. The drug, which was adsorbed on the surface of glassy carbon electrode, showed a sharp oxidative stripping peak at about +0.7 V (vs. Ag-AgCl) in voltammetry. The response was linear over the 0.01-1 microgram/ml concentration range. The detection limit was 2 ng/ml, about 400 times higher than UV method. The electrode surface was polished with alumina between the measurements to activate the electrode and provide good reproducibility. The open circuit accumulation/medium exchange/stripping voltammetry scheme has been proposed to avoid interference. The method has been used for direct determination of chlorprothixene in tablets and urine samples.