Superiority of combined chemo-embolization and portal infusion with 5-fluorouracil over locoregional infusion concepts in Novikoff hepatoma-bearing rats |
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Authors: | Hermann Bödeker Ernst-Jan Kamphorst Peter H Wünsch Ulrich Linnemann Martin R Berger |
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Institution: | (1) Department for Oncologic Surgery, Municipal Hospital Erding, 85435 Erding, Germany;(2) Unit of Toxicology and Chemotherapy, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, 69126 Heidelberg, Germany;(3) Institute for Pathology, Municipal Hospital Nürnberg Nord, 90419 Nürnberg, Germany;(4) Department for Abdominal, Thoracic and Endocrine Surgery, Municipal Hospital Nürnberg Nord, 90419 Nürnberg, Germany |
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Abstract: | The aim of this study was to investigate experimentally whether there is a superior effect of the combination of hepatic artery chemo-embolization with portal vein infusion over either of the two treatment modalities alone. Novikoff hepatoma cells transplanted under the liver capsule of Sprague Dawley rats were used as a model. Tumor growth was assessed at 7 and 21 days after tumor inoculation. The prolamine solution Ethibloc was employed for embolization, and 5-fluorouracil was used as a chemotherapeutic agent for both infusion and chemo-embolization. All arterial treatment modalities were administered in a super-selective manner. There was no intolerable toxicity after dosages of 55 to 125 mg 5-fluorouracil/kg body weight. With regard to therapeutic efficacy the results show that embolization is an effective therapeutic means for inducing tumor necrosis in selected liver areas. As a consequence, the ranking of all treatment modalities was based on the combined evaluation of tumor size and extent of tumor necrosis. According to this evaluation, hepatic artery chemo-embolization was superior to the respective type of infusion (P<0.01). In addition, the combination of both modalities in the form of hepatic artery chemo-embolization and portal vein infusion was effective in destroying more than 97% of vital tumor tissue (P<0.01). These results suggest the need for a comparative clinical study. |
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Keywords: | Chemoembolization Locoregional therapy Liver tumor Ethibloc |
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