心肌损伤标志物监测在急性心肌梗死中的临床应用

目的对心肌肌红蛋白（Mb）和心肌肌钙蛋白Ⅰ（cTnⅠ）进行定时、定量分析比较，为急性心肌梗死（AMI）的早期诊断、风险预测提供较合理的检测指标。方法用116例AMI患者在入院后24h内按时间段0～4h、～8h、～12h、～24h、～48h、～3d、～5d的血清检测cTnⅠ与Mb水平，同时对照46例正常血清进行结果比较并进行评估。结果AMI中cTnⅠ和Mb联合检测是合理的检测指标。结论CTnⅠ与Mb联合检测敏感性比单项检测要高。

Clinical application of monitoring of myocardial injury markers in acute myocardial infarction

Objective Timing and quantitative analysis was performed for myocardial myohemoglobin （Mb） and cardiac troponin Ⅰ （cTnⅠ） so as to provide available detective index in the early diagnosis of acute myocardial infraction （AMI） and risk prediction. Methods According to the admission time, 116 patients with acute myocardial infarction （AMI） were gruped into 0-4 h, -8 h, -12 h, -24 h, -8 h. -3 d. and -5 d group. Serum cTnⅠ and Mb were detected in 116 AMI patients at various time points and 46 healthy controls. Results The serum Mb level elevation started at 1 h after onset, reached to the peak value at 12 h, decreased step by step at 24 h, and restored at 72 h. By comparison, serum cTnⅠ level elevation started at 4 h after onset, and kept high value in the duration of 8-72 h. The study showed that the sensitivity of Mb was higher than that of cTnⅠ, but persistence time of positive result shorter than that of cTnⅠ. Conclusion The sensitivity of combined detection was markedly higher than that of detection alone.