我院金葡菌耐药水平变化与8种抗菌药物用量的相关性研究

目的：分析我院金葡菌耐药水平变化与抗菌药物用量的关系，为临床合理应用抗菌药物提供科学依据。方法：将我院住院部2004年1月-2006年12月抗菌药物使用情况以及金葡菌的药敏试验结果用SPSS13．0统计软件对结果进行数据分析。结果：金葡菌对环丙沙星耐药率与头孢唑啉用量、亚胺培南用量有显著的线性依存关系，亚胺培南用量为正方向影响，头孢唑啉用量为负方向影响；金葡菌对头孢唑啉耐药率与亚胺培南用量有显著的线性依存关系；金葡菌对亚胺培南耐药率与亚胺培南用量有显著的线性依存关系，且均为正方向影响。结论：金葡菌的耐药水平变化与抗菌药物的使用量有相关性，临床应有规律地轮换、限制使用抗菌药物．减少耐药菌的产生。

RESEARCH OF THE RELATIONSHIP BETWEEN THE DOSAGE OF ANTIBIOTICE AND THE LEVEL OF STAPHYLOCOCCUS RESISTANCE IN OUR HOSPITAL

Objective：To andlyze the quantitative relationship between the level of Staphylococcus resistance and the dosage of antibiotices so as to provide scientific foundation for the rational antibiotic therapy. Methods： The dosage of 8 kinds of antibiotics in-patient department of our hospital from January 2004 to December 2006 and the results of Staphylococcus aureus Sensitivity-test were investigated and analyzed by SPSS13.0 software. Results：The consumption amount of cefazolinum cnegatively and Imipenem positively related to the resistance of Staphylococcus aureus against Ciprofloxacin. The consumption amount of Cephalothin and Oxacillin correlated to the resistance of Staphylococcus aureus against cefazolinum. The consumption amount of Imipenem positively cor- related to the resistance of Staphylococcus aureus against cefazolin. The consumption amount of Imipenem posi- tively correlated to the resistance of Staphylococcus aureus against Imipenem. Conclusion：The drug-resistance levels of Staphylococcus aureus was correlated to the consumption amount of Antibiotics. Antibiotics should be used restrictly and regularly by turn in order to reduce the occurrence of drug resistance.