| 脑靶向紫杉醇纳米胶束的体外实验研究 |
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| 引用本文： | 陆恒,王雅杰.脑靶向紫杉醇纳米胶束的体外实验研究[J].医学研究杂志,2017,46(5):55-59. |
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| 作者姓名： | 陆恒 王雅杰 |
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| 作者单位： | 200433 上海, 第二军医大学附属长海医院,200433 上海, 第二军医大学附属长海医院 |
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| 基金项目： | 上海市自然科学基金资助项目（13NM1401504） |
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| 摘 要： | 目的 研发一种新型的治疗乳腺癌脑转移的靶向递药系统。方法 采用薄膜水化法制备载药胶束，将胶束与脑靶向分子Angiopep-2连接，使胶束具有脑靶向功能。结果 体外细胞实验证实该胶束具有良好的靶向性。结论 连接有靶向分子Angiopep-2的纳米胶束具有良好的脑靶向功能。
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| 关 键 词： | 乳腺癌 脑转移 纳米 靶向 胶束 |
| 收稿时间： | 2016/11/21 0:00:00 |
| 修稿时间： | 2016/11/29 0:00:00 |
Brain Targeting Drug Nano Micelle in Vitro Experimental Study |
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| Lu Heng and Wang Yajie.Brain Targeting Drug Nano Micelle in Vitro Experimental Study[J].Journal of Medical Research,2017,46(5):55-59. |
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| Authors: | Lu Heng and Wang Yajie |
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| Institution: | Changhai Hospital, Second Military Medical University, Shanghai 200433, China and Changhai Hospital, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective To develop a novel targeted delivery system for the treatment of brain metastases from breast cancer. Methods Micelles were prepared by membrane hydration method, and the micelles were connected to Angiopep-2. Results The micelles were confirmed to be well targeted in vitro. Conclusion Nano-particles with the targeting molecule Angiopep-2 has good brain-targeting function. |
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| Keywords: | Breast cancer Brain Metastases Nano Targeting Micelles |
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