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| 氟伐他汀对放射性肺损伤TGF-β1的影响 | |
| 引用本文： | 叶江枫,戚好文,范风云,赵峰,魏文胜,赵一岭,石梅. 氟伐他汀对放射性肺损伤TGF-β1的影响[J]. 医学争鸣, 2002, 23(13): 1184-1186 |
| 作者姓名： | 叶江枫 戚好文 范风云 赵峰 魏文胜 赵一岭 石梅 |
| 作者单位： | 1. 第四军医大学西京医院呼吸内科,陕西,西安,710033 2. 第四军医大学西京医院放射治疗科,陕西,西安,710033 3. 第四军医大学基础部病理学教研室,陕西,西安,710033 |
| 摘 要： | 目的探讨氟伐他汀(fluvastatin)对放射性肺损伤TGF-β1表达的影响. 方法将SD大鼠随机分为对照组、单纯照射组和氟伐他汀防治组,防治组于照射前1 wk以氟伐他汀20 mg*kg-1灌胃,1次*d-1, 直至实验结束.其他组灌服生理盐水.直线加速器全胸部照射,单次剂量为20 Gy,照后5,15,30和60 d剪开胸腔, 取肺组织做病理切片,并作TGF-β1免疫组化染色, 光镜下观察染色结果. 结果放疗组显示随着照射后时间延长, TGF-β1在肺组织表达逐渐增强, 氟伐他汀防治组显示TGF-β1的表达不随病情发展而增强. 与各时间点放射组相比明显减弱. 结论氟伐他汀能明显减弱TGF-β1表达,为防治放射性肺损伤提供了实验依据. |
| 关 键 词： | 氟伐他汀 放射性肺损伤 转化生长因子β 放射治疗 级联反应 细胞因子 |
| 文章编号： | 1000-2790(2002)13-1184-03 |
| 修稿时间： | 2002-03-08 |
Effect of fluvastatin on transforming growth factor beta1 in rats with radiation-induced lung injury |
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| YE Jiang Feng ,QI Hao Wen ,FAN Feng Yun ,ZHAO Feng ,WEI Wen Sheng ,ZHAO Yi Ling ,SHI Mei. Effect of fluvastatin on transforming growth factor beta1 in rats with radiation-induced lung injury[J]. Negative, 2002, 23(13): 1184-1186 | |
| Authors: | YE Jiang Feng QI Hao Wen FAN Feng Yun ZHAO Feng WEI Wen Sheng ZHAO Yi Ling SHI Mei |
| Affiliation: | YE Jiang Feng 1,QI Hao Wen 1,FAN Feng Yun 2,ZHAO Feng 1,WEI Wen Sheng 2,ZHAO Yi Ling 3,SHI Mei 2 1Department of Respiratory Diseases,2Department of Radiation Therapy,Xijing Hospital,3Department of Pathology,Faculty |
| Abstract: | AIM To investigate the effects of fluvastatin on transforming growth factor beta 1 (TGF beta 1) in rats with radiation induced lung injury. METHODS SD rats were divided randomly into 3 groups: normal control, irradiated control, rats irradiated and treated with fluvastatin. Two groups of rats were irradiated with x rays at a dose of 20 Gy thoracically. Seven days before the irradiation the rats in the fluvastatin group started the treatment with fluvastatin at a dose of 20 mg per day by garaging and continued to the end of the experiment. Tissues of lung were fecthed at different times. TGF beta 1 expression was measured by immunohistochemicall staining. RESULTS There was a significantly increase in the expression of TGF beta 1 in association with the increase of time in the irradiation group. The expression of TGF beta 1 in the irradiation treatment group was dim, compared with the irradiation group. CONCLUSION Fluvastatin down regulated TGF beta 1 expression, which indicated that the degree of irradiation induced lung injury was reduced. |
| Keywords: | fluvastatin radiation induced lung injury transforming growth factor beta |
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