均匀设计法对中药贴敷剂基质配方的研究

 目的:探讨影响中药贴敷剂(CTCM)主要制备工艺条件，并对CTCM进行质童检查。方法:采用均匀设计方法，对钻合剂、无机盐、充填剂、乳化剂、保湿剂、乙烯聚合物进行U₇(7⁶)的实脸，得出最优配比组成，对CTCM做初粘性、持粘性、粘着力、耐寒、耐热、粘数性、刺激性及致敏性试验。结果:CTCM具有载药量大，贴敷性能好，稳定性高，无致敏性与刺激性。基质适用性广，可与任何中药提取物配合，制备工艺简单，可直接采用硬膏涂布机进行生产，一降低了工艺中涂布烘干温度，减少中药有效成分的分解及挥发性成分的挥散，明显提高皮肤给药的治疗效果。结论:CTCM符合临床使用的要求。

Cataplamat of traditional Chinese medicine

OBJECTIVES:To investigate the preparing technicues,factors affecting the main characteristics of cataplamat of traditional Chinese medicine(CTCM),and to determine CTCM quality.METHODS:Using homogeneous design optimum seeking method,we obtained the optimal preparing conditions through experiment on six factors:adhesive(A),inorganic salt(B),filling agent(C),emulsifier(D),maintainable mosit agent(E),vingl polymer(F).Mass analyzsis of CTCM prepared according to these conditions was made,such as viscosity for the firstime/continued viscosity/adhesion/cold resistantce/heat resistance/adhesion/irritation tests.RESULTS:The volume of drug in CTCM was large,the adhesion appropriate,the adhesiveness better.The stability was higher.No sensitization and irritation.The substrates could coordinate any extracts of traditional Chinese medicine.CONCLUSION:CTCM prepared in our laboratory corresponds with clinical use,and could be used as a new plaster.