Role of fibroblasts as the principal factor in differentiation of the epidermis |
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| Authors: | N V Konstantinova R D Urso N G Korotkii N A Konstantinova M Duvic |
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| Institution: | (1) Russian State Medical University, Moscow;(2) Department of Dermatology and Department of Ophthalmology, University of Texas, Houston |
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| Abstract: | The role of fibroblasts in the differentiation of the epidermis and its relationships with other somatic cells, specifically,
keratinocytes, are studied using a skin equivalent formed from various types of fibroblasts separated from thoracic skin of
a healthy donor, apparently healthy skin sites and plaques from a patient with psoriasis, keloids and upper eyelid skin of
a normal subject, and keratinocytes separated from the umbilical skin of a newborn. Fibroblasts are shown to be active participants
in the differentiation and formation of epidermis specificity. Various types of fibroblasts form a histologically different
skin equivalent possessing the specific properties of the epidermis of the skin sites from which they were isolated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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1, pp. 80–84, January, 1996
Presented by R. V. Petrov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | fibroblasts keratinocytes skin equivalent cell-to-cell cooperation |
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