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Effect of fenoprofen on thyroid function tests
Authors:J Tillman  J T Leask  J Campbell  F C Logue  W D Fraser
Institution:1. Department of Medicine, Section of Endocrinology, Loyola University Medical Center, Maywood, Illinois;2. Department of Medicine, Section of Endocrinology, Edward Hines Junior VA Hospital, Hines, Illinois;3. Departments of Pathology and Pharmacology, Loyola University Medical Center, Maywood, Illinois.;1. Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84018, USA;2. School of Medicine, University of Utah, 30 N. 1900 E, Salt Lake City, UT 84132, USA;3. Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX 77550, USA;4. Division of Geriatrics, 30 N 1900 E, Room 4B120, University of Utah, Salt Lake City, UT 84132, USA;5. VA Salt Lake City Geriatric Research, Education, and Clinical Center, Salt Lake City, UT 84148, USA;6. Department of Nutrition and Integrative Physiology, University of Utah, 250 S. 1850 E, RM 214, Salt Lake City, UT 84112, USA;1. Medical Department IV, University Munich, Campus Grosshadern, Marchioninistraße 15, 81377 Munich, Germany;2. Department of Neurology, Endokrinologikum Frankfurt, Stresemannallee 1/3, 60596 Frankfurt/Main, Germany;3. Department of laboratory medicine and microbiology, Am Prime Parc 13, 65479 Raunheim, Germany;4. Department of Endocrinology, Endokrinologikum Frankfurt, Stresemannallee 1/3, 60596 Frankfurt/Main, Germany
Abstract:We observed that a few patients taking the anti-inflammatory drug fenoprofen showed increases in total and free T3 serum levels without convincing evidence of an associated thyrotoxicosis. To confirm these findings, two volunteers were given fenoprofen for two weeks. Within this time total T3 levels almost doubled and free T3 levels increased threefold. Administration of fenoprofen did not have any measurable effect on T4 or TSH estimations. Cross-reactivities of fenoprofen and 4'-hydroxyfenoprofen were studied with antisera from various total and free T3 assays. Results show that the metabolite cross-reacts with the antisera from Amerlex total and free T3 assay kits. A lesser degree of interference was observed with the Corning total and free T3 assays. 4'-hydroxyfenoprofen had no effect on an 'in house' total T3 assay. Laboratories should therefore be aware of the possibility that their assay may be subject to interference by fenoprofen or its metabolites while clinicians should be aware of this interference in order that they may avoid unnecessary and harmful treatment.
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