甲基多巴联合苯磺酸氨氯地平对妊娠高血压疾病的疗效研究

目的 研究甲基多巴片联合苯磺酸氨氯地平片对妊娠高血压疾病的疗效。方法 选择2016年1月—2019年1月西安交通大学医学部附属三二〇一医院收治的74例妊娠高血压疾病患者作为研究对象，根据入院的顺序，采用数字表法将患者随机分为两组。其中对照组清晨空腹服用苯磺酸氨氯地平片，5 mg/次，1次/d。观察组联合口服甲基多巴片，250 mg/次，3次/d。两组均给药1周。观察两组的临床疗效，比较两组患者的妊娠结局，血压、血肌酐（Cr）、尿素氮（BUN）和24 h尿蛋白水平。结果 治疗后，观察组治疗的总有效率显著高于对照组（P<0.05）。治疗后，观察组的胎盘早剥率、产后出血率、胎儿窘迫率、剖宫产率、低体质量儿率以及新生儿窒息率均明显低于对照组（P<0.05）。两组治疗后的收缩压（SBP）、平均动脉压（MAP）和舒张压（DBP）均明显降低（P<0.05），且观察组显著低于对照组（P<0.05）。两组治疗后的24 h尿蛋白水平均显著降低（P<0.05），且观察组显著低于对照组（P<0.05），而Cr和BUN水平治疗前后两组均无统计学差异。结论 甲基多巴片联合苯磺酸氨氯地平片对妊娠高血压疾病具有较好的疗效，能有效控制血压，改善妊娠结局和肾功能。

Efficacy of methyldopa combined with amlodipine besylate in treatment of gestational hypertension

Objective To study the efficacy of Methyldopa Tablets combined with Amlodipine Besylate Tablets on gestational hypertension. Methods Patients (74cases) with gestational hypertension who were admitted to Xi ''an Jiaotong University Affiliated to Medicine 321 Hospital from January 2016 to January 2019 were randomly divided into two groups according to the order of admission. Patients in the control group were po administered with Amlodipine Besylate Tablets in the morning, 5 mg/time, once daily. Patients in the observation group was combined with oral Methyldopa Tablets, 250 mg/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and pregnancy outcome, blood pressure, the levels of Cr, BUN, and 24 h urine protein in two groups were compared. Results After treatment, the total effective rate in the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the placental abruption rate, postpartum hemorrhage rate, fetal distress rate, cesarean section rate, low birth weight rate, and neonatal asphyxia rate in the observation group were significantly lower than those in the control group (P < 0.05). The SBP, MAP and DBP in two groups were significantly decreased after treatment (P < 0.05), and the observation group was significantly lower than those in the control group (P < 0.05). The 24 h urine protein levels were significantly decreased in two groups after treatment (P < 0.05). The observation group was lower than control group (P < 0.05), but Cr and BUN was no significant difference between two groups before and after treatment. Conclusion Methyldopa Tablets combined with Amlodipine Besylate Tablets has a good curative effect on gestational hypertension. It can effectively control blood pressure and improve pregnancy outcome and renal function.