青少年肥胖与Ghrelin相关性分析

【目的】探讨青少年肥胖与生长激素释放肽（Ghrelin）的关系。【方法】158名13～15岁青少年，根据体重指数（BMI）分为对照组80例，超重组44例和肥胖组34例。测量身高、体重及腰围（WC）。空腹静脉采血，应用酶联免疫吸附法检测血清真胰岛素（TI）和Ghrelin水平。【结果】①超重组BMI、WC和空腹血糖（FPG）高于对照组（P〈0．05），肥胖组BMI和wc高于超重组（P〈0．05），超重组和肥胖组TI和胰岛素抵抗指数（HOMA-IR）均高于对照组（P〈0．01），三组间Ghrelin水平比较差异无显著性（P〉0．05）。②Ghre-1in与FPG和ln（HOM站IR）存在单变量相关。多元线性回归显示以Ghrelin为因变量，在校正年龄、性别和BMI后，FPG和ln（HOMA—IR）为独立危险因素。③三组分别进行多元线性回归分析显示，对照组FPG、超重组ln（HOMA-IR）和FPG、肥胖组ln（HOMA—IR）分别为Ghrelin独立危险因素。【结论】FPG水平和胰岛素抵抗（insulin resistance，IR）是导致青少年血Ghrelin水平变化的独立危险因素，在肥胖青少年IR，而非FPG，可能是Ghrelin水平变化的独立预测因素。。

Relationship Between Obesity and Ghrelin in Adolescent

Objective] To explore the relationship between obesity and ghrelin in adolescent. Methods]A total of 158 adolescents aged 13-15 years were divided into control group（ n = 80）, overweight group（ n = 44） and obesity group（ n = 34） according to body mass index（BMI）. Height, weight and waist circumference （WC） were measured. Blood samples were collected. Serum true insulin（TI） and ghrelin were assayed by ELISA. Results] Overweight group had significantly higher levels of BMI, WC and fasting plasma glucose （FPG） than control group （ P 〈0.05）. Obesity group had significantly higher levels of BMI and WC than overweight group （ P 〈0.05）. Overweight and obesity group had significantly higher levels of TI and insulin resistance index （HOMA-IR） than control group（ P 〈0.01）. Ghrelin levels among three groups showed no significant difference（ P 〉0.05）. Ghrelin was positive correlation with FPG and ln（HOMA-IR）. Multiple linear regression analysis using ghrelin as the dependent variable showed that FPG and ln（HOMA-iR） were sig- nificant independent predictors for ghrelin adjusted for age, sex, BMI and blood pressure. Multiple linear regression analysis in three group respectively showed that FPG in control group, ln（HOMA-IR） and FPG in overweight group and ln（HOMA-IR） in obesity group were significant independent predictors for ghrelin, respectively. Conclusion]FPG levels and IR are the independent risk factors of blood ghrelin levels in adoles- cent. IR, but not FPG levels, may be the independent predisposed factor for ghrelin levels in obese adolescents.