ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans |
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| Authors: | M J Kreek J Ragunath S Plevy D Hamer B Schneider N Hartman |
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| Abstract: | Normal responses to metyrapone were observed in most steady-state methadone maintained treatment patients. These preliminary studies suggest that in recently detoxified methadone maintained treatment patients, there may be an exaggerated response of the hypothalamic-pituitary-adrenal axis to metyrapone. |
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