血浆氨基末端B型钠尿肽前体及组织多普勒成像评价左室舒张功能不全价值的研究

目的 探讨血浆氨基末端B型钠尿肽前体(NT-proBNP)及组织多普勒成像评价左室舒张功能不全的价值.方法 选择舒张性心力衰竭患者43例,根据舒张早期二尖瓣口血流速度(E)与舒张早期二尖瓣环运动速度(Em)的比值将患者分为三组:E/Em＜8为Ⅰ组,E/Em 8～15为Ⅱ组,E/Em＞15为Ⅲ组.测定三组患者血浆NT-proBNP水平,并进行比较.结果 Ⅲ组NT-proBNP水平(1119±3123)ng/L]显著高于Ⅱ组(684±1742)ng/L]和Ⅰ组(276±438)ng/L](P＜0.01),Ⅱ组NT-proBNP水平显著高于Ⅰ组(P＜0.01).相关性分析表明E/Em与NT-proBNP具有相关性(r=0.438,P＜0.01).结论 血浆NT-proBNP水平及组织多普勒成像可用于评价左室舒张功能不全.

Clinical study of N-terminal prohormone brain natriuretic peptide and tissue Doppler imaging in left ventricular diastolic dysfunction

Objective To evaluate the value of N-terminal prohormone brain natriuretic peptide (NT-proBNP) and tissue Doppler imaging (TDI) in patients with left ventricular diastolic dysfunction.Methods Forty-three patients with diastolic heart failure were enrolled. Pulsed wave (PW) Doppler technology was used to detect early diastolic mitral velocity (E) and TDI was performed to determine the mitral annulus velocity of early diastolic phase (Em). According to the E/Em, patients were divided into three groups: group Ⅰ (E/Em ＜8),group Ⅱ (E/Em 8-15) and group Ⅲ (E/Em ＞ 15). The plasma NT-proBNP was measured. Results The plasma NT-proBNP in group Ⅲ ( 1119 ± 3123) ng/L] was higher than that in group Ⅱ (684± 1742) ng/L] and group Ⅰ (276±438) ng/L] (P＜0.01),and the plasma NT-proBNP in group Ⅱ was higher than that in group Ⅰ (P ＜ 0.01 ). The plasma NT-proBNP had positive correlation with E/Em (r = 0.438,P ＜ 0.01 ). Conclusion The plasma NT-proBNP and TDI are useful to evaluate the left ventricular diastolic dysfunction.