| 姜黄素衍生物FM0817体外抗肿瘤活性研究 |
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| 引用本文： | 张南文,刘洋,许建华,陈崇宏. 姜黄素衍生物FM0817体外抗肿瘤活性研究[J]. 海峡药学, 2009, 21(5): 39-41 |
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| 作者姓名： | 张南文 刘洋 许建华 陈崇宏 |
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| 作者单位： | 福建医科大学药学院临床药理研究所;福建医科大学药学院药理学系,福州,350004;福建医科大学药学院临床药理研究所;福建医科大学药学院药理学系,福州,350004 |
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| 摘 要： | 目的对比研究姜黄素衍生物FM0817与姜黄素对9株体外培养肿瘤细胞的增殖抑制作用。方法应用MTT法检测黄素衍生物FM0817与姜黄素耐9株体外培养肿瘤细胞的增殖抑制率。结果黄素衍生物FM0817与姜黄素对9株肿瘤细胞Ic50平均值分别为1．95μg·mL^-1和10．84μg·mL^-1，FM0817对多种肿瘤细胞的增殖抑制作用明显强于其母核姜黄素。结论姜黄素衍生物FM0817具有较强的体外抗肿瘤活性，有进一步开发研究的前景。
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| 关 键 词： | 姜黄素 衍生物 抗肿瘤 |
Study of anti-tumor effect of curcumin derivative FM 0817 in vitro |
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| ZHANG Nan-wen,LIU Yang,XU Jian-hua,CHEN Chong-hong. Study of anti-tumor effect of curcumin derivative FM 0817 in vitro[J]. Strait Pharmaceutical Journal, 2009, 21(5): 39-41 |
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| Authors: | ZHANG Nan-wen LIU Yang XU Jian-hua CHEN Chong-hong |
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| Affiliation: | ZHANG Nan-wen, LIU Yang, XU Jian-hua, CHEN Chong-hong ( 1. Institute of Clinical Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; 2. Department of Pharmacology, School of Pharmacy, Fujian Medical University , Fuzhou 350004, China) |
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| Abstract: | OBJECTIVE Contrast study of antitumor effects of curcumin derivative FM0817 and curcumin on nine tumor cell lines in vitro.METHODS MTT assay was used to determine the anti-proliferative ratio of FM0817 and curcumin on the nine tumor cell lines in vitro. RESULTS The average IC50 of FM0817 and curcumin on the nine tumor cell lines was 1.95μg·mL^-1 and 10.84μg·mL^-1, the antitumor effect of FM0817 was potenter than curcumin. CONCLUSIONS FM0817 exhibits potenter activity in antitumor in vitro, deserves further research and development. |
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| Keywords: | Curcumin Derivative Antitumor |
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