七氟醚的合成 |
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引用本文: | 李斌栋,吕春绪,冯超.七氟醚的合成[J].中国医药工业杂志,2007,38(10):681-682. |
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作者姓名: | 李斌栋 吕春绪 冯超 |
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作者单位: | 南京理工大学化工学院,江苏南京,210094 |
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摘 要: | 六氟丙烯经硫二聚、氧化、还原、氯甲基化和氟代等反应合成七氟醚,总收率约76%。其中六氟丙酮利用Ni—B非晶态合金催化还原的收率可达98%;利用微波促进在离子液体中氟代的收率可达98.6%.
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关 键 词: | 七氟醚 麻醉剂 合成 |
文章编号: | 1001-8255(2007)10-0681-02 |
修稿时间: | 2007-07-13 |
Synthesis of Sevoflurane |
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Authors: | LI Bin-dong LU Chun-xu FENG Chao |
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Abstract: | Sevoflurane was synthesized from hexafluoropropene by hexafluorothioacetone dimerisation, oxidation, and then hydrogenation under the catalysis of Ni-B amorphous alloy, followed by chloromethylation and fluoride exchange in the promotion of both microwave and the ionic liquid with an overall yield of about 76 %. |
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Keywords: | sevoflurane anesthetics synthesis |
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