前S1抗原在CHB检测中的意义

目的验证前S1抗原在HBV组合检测中的价值。方法收集门诊同步检测HBVDNA、HBVM、ALT／AST的288份血清，应用ELISA方法检测前s1抗原。结果288份血清中男175份，女113份，中位年龄36．89岁，均为CHB。其中pre-S1Ag（＋）197份（68．4％），HBVDNA〉5．0E＋2copy／ml 161份（55．9％），eAg（＋）71份（24．6％），eAg（-）186份（64．58％），ALT／AST〉42／50u／ml、ALT〉40u／ml64份（22．2％，AST〉50u／Inl60份（20．8％）。分P．S1Ag（＋）和P—S1Ag（-）两组，在P—S1Ag（＋）组中HBVDNA〉界值124例占62．9％，HBeAg阴性118份占59．8％占优势：分析HBVDNA阳性率和病毒血症水平P—S1Ag（＋）和P-s1Ag（-）在低于界值时各为35．2％和63．6％，在低于10^3 copy／ml时各为56．9％和81．7％，在10^5-10^8copy／ml时各为33％和14．3％；两组差异有统计学意义。结论P-S1Ag阳性在慢性乙肝中eAg阴性预疗病毒复制，协助诊断预后。

The value of detection pre-S1 antigen in patients with chronicity type B hepatitis (CHB)

Objective To evaluate the value of pre-S1 Ag in combined detection of hepatitis B virus. Methods 288 patients' serums with chronicity type B hepatitis (CHB)were collected when they had been detected with HBV-DNA,HBVM or ALT/AST,and then ELISA assay were applied to detect pre-S1Ag. Results A total of 288 patients ,including 175 males and 113 females( their meso-age is 36.89 years old) were recruited into this study. 161 patients were pre-S1 Ag positive(68.4%), 197 patients' HBV DNA contents exceeded 5.0E + 2 copy/ml(55.9%) ,71patients were H BeAg positive (24.6%), 186 patients were HBeAg negative (64.58%). The rate of 64 patients' ALT and AST exceeded 0. 84, and their' ALT exceeded 40 u/ml ( 22. 2% ). 60 patients' AST exceeded 50 u/ml (20. 8% ). These patients were divided into pre-S1 Ag positive group and pre-S1 Ag group. In pre-S1 Ag positive group, 124 patients' HBV DNA contents exceeded 5.0E + 2 copy/ml( 62.9% ), 118 patients were HBeAg negative (59.8%). When HBV DNA content was less than 5.0E+2 copy/ml,pre-S1 Ag positive rate was 35.2% and pre-S1 Ag negative rate was 63.6%. when HBV DNA content was less than 5.0E + 3 copy/ml, pre-S1 Ag positive rate was 56.9% and pre-S1 Ag negative rate was 81.7%. When HBV DNA content exceeded 5.0E + 5 copy/ml but less than 5.0E + 8 copy/ml ,pre-S1 Ag positive rate was 33% and pre-S1 Ag negative rate was 14.3% ,so two groups had significant difference. Conclusion Pre-S1 Ag positive and HBeAg negative in the CHB patients serums signify virus replication,and it can help us decide prognosis.