复方红曲提取物对高脂血症大鼠的降脂作用研究

目的:观察复方红曲提取物对灌胃脂肪乳剂所致高脂血症大鼠血脂、血液流变学及凝血系统的影响,以评价其降脂作用.方法:SD大鼠随机分为6组,分别为正常组、模型组、阳性对照药血脂康0.24 g·kg~(-1)组,复方红曲提取物0.6,1.2,2.4 g·kg~(-1) 3个剂量组.除正常组给予饮用水外,其余各组均以10 mL·kg~(-1)灌胃脂肪乳剂,2 d后阳性药组及复方红曲提取物各给药组开始给药,连续3周.末次给药后测定血脂、血液流变学及凝血因子指标.结果:复方红曲提取物2.4 g·kg~(-1)能明显降低高脂血症大鼠血清甘油三脂(TG),总胆固醇(TC)水平,升高高密度脂蛋白胆固醇(HDL-C)水平(P＜0.01,P＜0.05),对低密度脂蛋白胆固醇(LDL-C)有下调的趋势,但无统计学意义;复方红曲提取物各给药组的血清HDL-C/TC,HDL-C/TC,HDL-C/LDL-C比值均明显升高(P＜0.01).复方红曲提取物2.4 g·kg~(-1)能有效降低不同切变率下的全血黏度、延长活化部分凝血活酶时间、降低纤维蛋白原含量(P＜0.01,P＜0.05),0.6-2.4 g·kg~(-1)均能有效降低血浆黏度(P＜0.01～P＜0.05).结论:复方红曲提取物2.4 g·kg~(-1)能显著降低实验性高脂血症大鼠的血脂水平、血液黏度、纤维蛋白原含量,改善血液循环,抑制因血脂升高和脂质代谢紊乱引起的血液凝血系统指标的改变.

Lowered lipids efficiency of compound red yeast rice extractin rats with hyperlipidemia

Objective : To observe the effects of compound red yeast rice extract (CRYRE) on blood lipids, hemorheology and blood coagulant system in rats with hyperlipidemia. Method : SD rats were randomly divided into six groups: normal control group, model group, Xuezhikang group (0.24 g·kg^-1), CRYRE high dose group (2.4 g·kg^-1), middle dose group (1.2 g·kg^-1) and low dose group (0.6 g·kg^-1). The normal control rats were given pure water, and rats of other five groups were given 10 mL kg^-1 lipid emulsion and subjected to daily intragastric administration simultaneously in two days, continuously for 3 weeks. After the last medication, all the rats were sacrificed for measurement of blood lipids, hemorheology and coagulation factors. Result : CRYRE 2.4 g·kg^-1 could significantly reduce the serum TG, TC levels and increase the HDL-C level (P<0.01, P<0.05). CRYRE 0.6-2.4 g·kg^-1 could significantly increase the ratios of HDL-C/TG,HDL-C/TC and HDL-C/LDL-C (P<0.01). CRYRE 2.4 g·kg^-1 also reduced whole blood viscosity and plasma viscosity (P<0.01, P<0.05), prolonged active partial thromboplastin time, and lowered fibrinogen content(P<0.01, P<0.05). Conclusion : CRYRE 2.4 g·kg^-1 could reduce blood lipids, blood viscosity and fibrinogen content, improve blood circulation, and depress the alteration of blood coagulant system resulted from lipid metabolic disorder in rats with hyperlipidemia.