肿瘤转移相关基因-1及p73在子宫内膜癌中的表达及临床意义分析

目的观察肿瘤转移相关基因-1(metastasis-associated gene,MTA-1)及p 73在子宫内膜癌中的表达,探讨其在子宫内膜癌发生发展过程中的临床意义。方法选取2012年1月至2015年1月在大连市第三人民医院诊断的50例不典型增生子宫内膜(不典型增生组)与70例子宫内膜癌(子宫内膜癌组),并选取同期50例正常增生期子宫内膜(正常组)为对照,检测组织中MTA-1及p 73的表达情况,分析二者与子宫内膜癌临床和病理特征的关系。结果正常组、不典型增生组及子宫内膜癌组的MTA-1阳性表达率分别为6.00%、28.00%、78.57%,p 73阳性表达率分别为8.00%、30.00%、75.71%;子宫内膜癌组及不典型增生组的MTA-1及p 73阳性表达率均明显高于正常组(P0.05)。子宫内膜癌组的MTA-1及p 73阳性表达率亦明显高于不典型增生组(P0.05)。不同临床分期、分化程度、肌层浸润深度和淋巴结转移情况的子宫内膜癌组织中的MTA-1表达率相比较,差异均有统计学意义(P0.05)。不同临床分期和淋巴结转移情况的子宫内膜癌组织中的p 73表达率相比较,差异均有统计学意义(P0.05),而不同分化程度和肌层浸润深度组织中的p 73表达率相比较,差异无统计学意义(P0.05)。相关性分析表明,子宫内膜癌组织中的MTA-1和p 73表达呈正相关(r=0.472,P0.05)。结论 MTA-1及p 73在子宫内膜癌组织中的表达明显增多,二者在子宫内膜癌的发生发展过程中发挥了重要作用,对判断临床病理分期和有无转移存在重要的参考价值。

Expression of MTA-1 and p73 in endometrial carcinoma and its clinical significance

Objective To obverse the expression of metastasis-associated gene-1(MTA-1) and p73 in endometrial carcinoma and to discuss its clinical significance during the development of endometrial carcinoma.Methods 50 patients with atypical hyperplasia of endometrium (atypical hyperplasia group)and 70 patients with endometrial carcinoma (endometrial carcinoma group)diagnosed at Third People's Hospital of Dalian City from January 2012 to January 2015 were selected as research object.And 50 patients with normal endometrial hyperplasia (normal group) were selected as control.The expression of MTA-1 and p73 of all groups were detected and the relationship with clinical and pathological characteristics of endometrial carcinoma were analyzed.Results Positive expression rates of MTA-1 in normal group,atypical hyperplasia group and endometrial carcinoma group were 6.00%,28.00% and 78.57% respectively,and positive expression rates of p73 in normal group,atypical hyperplasia group and endometrial carcinoma group were 8.00%,30.00% and 75.71% respectively.Positive expression rates of MTA-1 and p73 of endometrial carcinoma group and atypical hyperplasia group were obviously higher than that of normal group,the differences were statistically significant(P<0.05);Positive expression rates of MTA-1 and p73 of endometrial carcinoma group were obviously higher than that of atypical hyperplasia group,the differences were also statistically significant(P<0.05).There were statistical significant differences in the expression of MTA-1 with different clinical stages,differentiation degrees,muscular infiltration depths and lymph node metastasis(P<0.05);There were statistical significant differences in the expression of p73 with different clinical stages and lymph node metastasis(P<0.05);There were no statistical significant differences in the expression of p73 with different differentiation degrees and muscular infiltration depths(P>0.05).Correlation analysis showed that in endometrial carcinoma tissue the expression of MTA 1 and p73 were positively related(r=0.472,P<0.05).Conclusion The expression of MTA-1 and p73 in endometrial carcinoma tissues is significantly increased and they both play an important role in the development and progression of endometrial carcinoma and have important reference value in judging the clinical pathological stage and the presence or absence of metastasis.