雌三醇软膏与乳酸菌阴道胶囊联合治疗老年性阴道炎疗效观察

目的:观察雌三醇软膏与乳酸菌阴道胶囊联合治疗老年性阴道炎(SV)的疗效。方法:选取2012年2月至2016年月3在南京市中心医院和南京市第二医院接受治疗的84例老年性阴道炎患者作为研究对象,年龄56~68岁,平均年龄61.5岁,将对象随机分为观察组(42例)和对照组(42例)。观察组患者给予以阴道外用雌三醇软膏0.5mg/次、乳酸菌阴道胶囊0.5g,每晚各1次,连用6周。对照组患者仅用雌三醇软膏或乳酸菌阴道胶囊,其用法、剂量和疗程与观察组保持相同。观察两组治疗后的临床疗效和安全性,并随访治疗后半年的复发率。结果:治疗6周后,观察组患者临床总有效率为95.24%,明显高于对照组使用雌三醇软膏或使用乳酸菌阴道胶囊73.81%(P<0.05),治疗后两组患者虽然出现了一些不良反应,但是不影响后续治疗;随访半年后发现观察组复发3例(7.14%),对照组复发17例(40.48%),观察组患者的复发率明显低于对照组患者的发病率(P<0.05)。结论:雌三醇软膏与乳酸菌阴道胶囊联合治疗老年性阴道炎疗效明显,改善临床症状明显,可降低复发率。

Curative effect observation of estriol ointment and lacidophilin vaginal capsules in treatment of senile vaginitis

Objectives:To observe the effect of estriol ointment and lacidophilin vaginal capsules for the treatment of senile vaginitis (SV).Methods:A total of 84 SV patients aged 56-68 with mean age of 61.5 in our hospital from February 2012 to March 2016 were enrolled.The subjects were randomly divided into observation group (42 cases) and control group (n =42).Patients in the observation group were given topical vaginal estriol ointment 0.5 mg / time,lactic acid bacteria vaginal capsule 0.5 g,once a night for 6 weeks.In the control group,only estriol ointment or lactic acid vaginal capsule was used.The dosage,duration and duration of treatment in control group were the same as those of observation group.The clinical efficacy and safety of two groups were observed,and the recurrence rate was observed after six months of follow-up.Results:After 6 weeks of treatment,the total effective rate of observation group was 95.24％,which was significantly higher than that of control group (73.81％,P ＜ 0.05).After 6 weeks of treatment,the recurrence in observation group was 7.14％ and 40.48％ in the control group,with significant difference (P ＜ 0.05).Conclusion:The combination treatment of estriol ointment and lactobacillus vaginal capsule has obvious effect in the treatment of SV.It can improve the clinical symptoms and reduce the relapse rate.