间苯三酚对IVF/ICSI-ET治疗出现子宫内膜负向蠕动波的不孕患者的临床效果分析

目的探讨体外受精/胞浆内单精子注射-胚胎移植(in vitro fertilization/intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)治疗不孕过程中使用间苯三酚对患者的临床效果。方法选取2014年10月至2015年3月在武汉大学人民医院进行IVF/ICSI-ET治疗出现子宫内膜负向蠕动波的不孕患者66例作为研究对象,按照随机数字表法将全部患者分为观察组(32例,使用间苯三酚注射液静脉滴注)和对照组(34例,未用间苯三酚)。对两组患者负向蠕动波的变化趋势进行观测记录,采用费雪确切概率法比较平滑肌解痉药物间苯三酚对IVF/ICSI-ET患者子宫内膜负向蠕动波水平、临床妊娠率、异位妊娠率、流产率以及妊娠结局的影响。结果观察组子宫内膜负向蠕动波消失率和增加率(87.50%,0%)与对照组(38.24%,29.41%)相比,差异有统计学意义(χ~2=17.003、11.092,P0.05)。观察组7 min内出现负向波频数低于对照组,差异有统计学意义(t=9.528,P0.05)。观察组临床妊娠率(62.50%)高于对照组(26.34%),差异有统计学意义(χ~2=8.687,P0.05)。观察组和对照组的流产率(6.25%vs 5.88%)和异位妊娠率(3.13%vs 15.63%)比较差异无统计学意义(P0.05)。结论间苯三酚应用于IVF/ICSI-ET治疗不孕患者,可以减少对子宫内膜的刺激,抑制子宫平滑肌痉挛性收缩,减少子宫内膜负向蠕动波,提高临床妊娠率。

Clinical effect of phloroglucinol on infertile patients with endometrial negative peristaltic wave undergoing IVF / ICSI-ET

Objective To investigate the clinical efficacy of phloroglucinol in the treatment of infertility in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI-ET).Methods A total of 66 infertile women with endometrial negative peristaltic wave treated with IVF / ICSI-ET in Renmin Hospital of Wuhan University from October 2014 to March 2015 were selected as study object.They were divided into observation group (32 cases, phloroglucinol intravenous infusion) and control group (34 cases) according to the random number table method.The changes of negative peristaltic wave in the observation group and the control group were observed.The effects of phloroglucinol on the levels of negative peristaltic wave, clinical pregnancy rate, ectopic pregnancy rate, abortion rate and pregnancy outcome in IVF/ICSI-ET patients were compared by Fisher exact probability method.Results Endometrial negative peristaltic wave disappearance rate and increase rate(87.50％,0％) of the observation group compared with the control group (38.24％, 29.41％) the differences were statistically significant(χ2=17.003,11.092,P<0.05).The frequency of negative peristaltic wave in the observation group was lower than that in the control group, the difference was statistically significant(t=9.528,P<0.05).The clinical pregnancy rate in the observation group(62.50％) was significantly higher than that in the control group(26.34％), the difference was statistically significant(χ2=8.687,P<0.05).There were no significant differences between the observation group and the control group on abortion rate (6.25％ vs 5.88％) and ectopic pregnancy rate (3.13％ vs 15.63％)(P> 0.05).Conclusion The use of phloroglucinol in IVF / ICSI-ET treatment of infertility can reduce the stimulation of the endometrium, inhibit uterine smooth muscle spasm contraction, reduce endometrial negative creep wave and improve clinical pregnancy rate.