不同滴度的妊娠梅毒患者的治疗结局分析

目的:探讨不同滴度的妊娠梅毒治疗后对治疗结局的分析。方法:回顾性分析2014年1月至2016年9月于我科治疗的120名妊娠梅毒患者作为本次试验的研究对象。将选取的120名妊娠梅毒患者根据妊娠梅毒确诊时的甲苯胺红不加热血清试验(TRUST滴度)的不同分为三组:分别为妊娠梅毒确诊时TRUST滴度小于1∶4、妊娠梅毒确诊时TRUST滴度1∶4~1∶8、妊娠梅毒确诊时TRUST滴度1∶8以上。TRUST滴度小于1∶4组患者30例,TRUST滴度1∶4~1∶8组患者50例,TRUST滴度1∶8以上组患者40例。然后对各组患者的妊娠结局进行统计学分析。结果:TRUST滴度<1∶4组自然流产1例(3.3%)、宫内死胎1例(3.3%)、早产儿2例(6.7%)、新生儿先天性梅毒1例(3.3%),不良妊娠结局的发生率为16.7%;TRUST滴度1∶4~1∶8组自然流产5例(10%)、宫内死胎3例(6%)、早产儿5例(10%)、新生儿先天性梅毒5例(10%),不良妊娠结局的发生率为36%;TRUST滴度>1∶8组自然流产5例(12.5%)、宫内死胎4例(10%)、早产儿8例(20%)、新生儿先天性梅毒7例(17.5%),不良妊娠结局的发生率为60%。结论:妊娠梅毒不同滴度的患者治疗结局不同,妊娠梅毒滴度越高不良妊娠结局的发生率越高。

Treatment outcome of patients with different titers of pregnant syphilis

Objectives:To study the treatment outcome of patients with different titers of pregnant syphilis.Methods:A retrospective analysis on 120 pregnant patients with syphilis treated in our department from January 2014 to September 2016 was done.According to the TRUST titer,they were divided into three groups:TRUST titer less than 1 ∶ 4 (30 cases),TRUST titer 1 ∶ 4-1 ∶ 8 (50 cases) and TRUST titer more than 8 (40 cases).Then pregnancy outcome of each patient was statistically analyzed.Results:In TRUST drops ＜ 1 ∶ 4 group,there were 1 case of natural abortion (3.3％),1 case of intrauterine demise (3.3％),2 cases of premature infants (6.7％)and 1 case of neonatal congenital syphilis (3.3％).The incidence of adverse pregnancy outcomes was 16.7％.In TRUST titer 1 ∶ 4-8 group,there were 5 cases of spontaneous abortion (10％),3 cases of intrauterine demise (6％),5 cases of premature infants (10％) and 5 cases of neonatal congenital syphilis (10％),and the incidence of adverse pregnancy outcomes was 36％.In TRUST titer ＞ 8 group,there were 5 cases of spontaneous abortion (12.5％),4 cases of intrauterine demise (10％),8 cases of premature (20％) and 7 cases of neonatal congenital syphilis in (17.5％),and the incidence of adverse pregnancy outcomes was 60％.Conclusion:The higher the titer of syphilis in pregnant patients is,the higher incidence of adverse pregnancy outcome is.