腹腔镜高位结扎联合复方玄驹胶囊治疗亚临床型精索静脉曲张不育的临床研究

目的:观察复方玄驹胶囊治疗亚临床型精索静脉曲张(Subclinical varicocele,SVC)不育疗效,以丰富治疗方法。方法:选择2011年4月3日至2015年4月2日SCV不育患者78例,按住院号单双随机平均分成对照组和试验组(n=39),对照组手术治疗,试验组加用复方玄驹胶囊口服,治疗3个月后进行精子参数、性激素和总疗效比较。结果:总疗效上,治疗3个月后对照组治愈率23.08%、总有效率74.36%,试验组治愈率46.16%、总有效率92.31%,试验组显著优于对照组(P<0.05);精液参数上,两组治疗3个月后在A级精子率、A+B级精子率、精子密度、精子总活率、精子直线速度、精子平均路径速度上较治疗前均显著提高,而精子畸形率较治疗前显著下降(P<0.05),且治疗3个月后试验组在A级精子率、A+B级精子率、精子密度、精子总活率、精子畸形率上显著优于对照组(P<0.05);性激素指标上,两组治疗3个月后在T水平较治疗前均显著提高,而FSH、LH较治疗前显著下降(P<0.05),且治疗3个月后试验组在T、FSH、LH水平显著优于对照组(P<0.05)。结论:复方玄驹胶囊辅助手术治疗SVC不育能提高精子质量,改善性激素水平,提高疗效。

Clinical study of laparoscopic varicocele high ligation combined with Fufang Xuanju capsule in the treatment of subclinical varicocele infertility

Objectives:To observe the effect of Fufang Xuanju capsule in the treatment of subclinical varicocele (Subclinical varicocele,SVC) infertility.Methods:78 infertile patients from April 3,2011 to April 2,2015 were randomly divided into control group and experimental group (n =39).Control group received surgical treatment and experimental group were treated with laparoscopic varicocele high ligation combined with Fufang Xuanju capsule.3 months after the treatment,the sperm parameters,sex hormones and the total effect of two groups were compared.Results:3 months after treatment,the cure rate and total efficiency of control group were 23.08％ and 74.36％,respectively.The cure rate and total efficiency of experimental group was 46.16％ and 92.31％,with significant differences (P ＜0.05).In the aspect of semen parameters,3 months after the treatment,the survival rate of sperm,a + b class sperm live rate,sperm density,sperm motility,total sperm motility,linear velocity and average path velocity of two groups were significantly increased,while the sperm deformity rate decreased significantly after treatment (P ＜ 0.05).At 3 months after treatment,the survival rate of sperm,a + b class sperm live rate,sperm density,sperm motility,total sperm motility,linear velocity and average path velocity of experimental group were significantly better than these of control group (P ＜ 0.05).In the aspect of sex hormone index,3 months after the treatment,the T level was significantly increased,while FSH and LH decreased significantly after treatment (P ＜0.05).At 3 months after treatment,the T,LH and FSH levels of experimental group were significantly higher than those in control group (P ＜ 0.05).Conclusion:Surgical treatment combined with Fufangxuanju capsule in the treatment of SVC infertility can improve sperm quality,the levels of sex hormones and the curative effect.