妊娠合并亚临床甲状腺功能减退症相关危险因素分析

目的探讨妊娠合并亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)的相关危险因素。方法选取2013年11月至2015年12月在成都市妇女儿童中心医院妇产科住院分娩的妊娠合并SCH患者519例为研究组,同期540例非SCH孕产妇为对照组,采用面对面询问和问卷调查方式收集两组的一般资料、本次怀孕前及孕期情况、既往妊娠史等,分析影响妊娠合并SCH的危险因素。结果相关单因素分析结果显示:年龄、孕产史、家庭人均月收入、文化程度、自然流产史、剖宫产、孕前体质量指数(body mass index,BMI)为影响妊娠合并SCH的单因素(P0.05);Logistic回归分析结果显示:年龄≥30岁、初产者、孕前BMI18.5 kg/m~2为影响妊娠合并SCH的危险因素(P0.05)。结论妊娠合并SCH的发生与孕妇年龄、孕产史、孕前BMI相关。

Analysis of risk factors associated with subclinical hypothyroidism in pregnancy

Objective To investigate the risk factors of pregnancy with subclinical hypothyroidism(SCH).Methods 519 pregnant women with SCH and 540 pregnant women without SCH were enrolled in this study from November 2013 to December 2015 in Chengdu Women & Children's Center Hospital.Face to face interview or questionnaires were used to collect general information,situation before and during pregnancy,previous pregnancy history of the two groups of patients.Analyzed the risk factors affecting pregnancy with SCH.Results The results of univariate analysis showed that age,maternity,family income,educational level,history of spontaneous abortion,cesarean section and pre-pregnancy body mass index (BMI) were the single factor influencing the pregnancy.The difference was statistically significant (P<0.05).Logistic regression analysis showed: Age≥30 years,beginning producers and pre-pregnancy BMI <18.5 kg/m2 were the risk factors for the pregnant women with SCH (P<0.05).Conclusion The incidence of SCH in pregnancy is related to maternal age,pregnancy history and BMI before pregnancy.