妊娠合并梅毒感染者发生不良妊娠结局的临床调查研究

目的:分析妊娠合并梅毒感染孕妇发生不良妊娠结局的影响因素,为妊娠合并梅毒感染孕妇临床治疗方案选择提供参考。方法:回顾性分析我院2010年12月至2015年10月期间收治的324例妊娠合并梅毒感染患者,统计孕妇出现不良妊娠结局的情况,比较不良妊娠结局和正常妊娠结局两组患者临床资料的差异,采用logistic多因素回归分析妊娠合并梅毒患者发生妊娠不良结局的影响因素。结果:324例妊娠合并梅毒感染患者中有24例(7.41%)出现不良妊娠结局,对正常组300例患者和不良结局组24例患者的临床资料分析,结果显示,产次、年龄、就诊时梅毒分期、其它传染病、驱梅疗程、随访执行情况是影响妊娠合并梅毒感染患者妊娠结局的相关因素;经logistic多因素回归分析,就诊时梅毒为中晚期期、有其它传染病、完成驱梅疗程≤1、未严格执行随访计划是妊娠合并梅毒感染患者妊娠结局不良的危险因素。结论:妊娠合并梅毒感染患者的不良妊娠结局发病率较高,影响妊娠合并梅毒感染不良妊娠结局的因素较多,在加强对孕妇进行梅毒筛查的同时,应加强梅毒感染孕妇的后续治疗和管理,确保梅毒感染得到有效控制,降低梅毒感染对妊娠结局的不良影响,提高孕妇的妊娠预后。

Clinical investigation on incidence of adverse pregnancy outcomes among pregnant women with syphilis infection

Objectives:To analyze the influencing factors of adverse pregnancy outcomes of pregnant women complicated with syphilis,in order to provide reference for the clinical treatment.Methods:A retrospective analysis of 324 pregnant women complicated with syphilis admitted in our hospital from December 2010 to October 2015 was conducted.The incidence of adverse pregnancy outcomes was surveyed and the clinical data of the two groups having different pregnancy outcomes was compared to analyze the influencing factors of adverse pregnancy outcomes.Then Logistic multivariate regression analysis was conducted for further analysis of risk factors,to explore measures to prevent the incidence of adverse pregnancy outcomes.Results:Among the 324 patients,24 ones (7.41％) had adverse pregnancy outcomes.According to the analysis of the clinical data,times of labor,age,syphilis stage,other infectious diseases,anti-syphilitic treatment and the implementation of follow-up treatment were all influencing factors of adverse pregnancy outcomes.According to multivariate logistic regression analysis,late syphilitic stage,other infectious diseases,completed anti-syphilitic course ≤ 1 and lenient implementation of follow-up treatment were all risk factors of adverse pregnancy outcomes.Conclusion:The incidence of adverse pregnancy outcomes is high among pregnant women complicated with syphilis,with many influencing factors.Therefore,timely screening,treatment and follow-up treatment and management should be provided to reduce the incidence of adverse pregnancy outcomes.