女童性早熟与环境内分泌干扰素的相关性研究

目的:探讨女童性早熟与环境内分泌干扰素相关性。方法:选取2010年2月至2015年2月115例性早熟女童作为观察组,选取同时期健康女性儿童115例作为对照组,均进行环境内分泌干扰素,并进行子宫体积、骨密度、血清雌二醇等水平检测,分析性早熟和环境内分泌干扰素相关性。结果:观察组EEDs指标DEHP、OP、BPA均显著低于对照组,两组比较差异显著(P<0.05);观察组子宫体积、卵巢体积、雌二醇、骨密度均显著低于对照组,两组比较差异显著(P<0.05);DEHP和子宫体积、卵巢体积、骨密度正相关(P分别为0.001、0.003、0.000),OP和子宫体积正相关(P=0.003),BPA和子宫体积、卵巢体积正相关(P分别为0.000、0.042)。结论:环境内分泌干扰素是儿童性早熟重要致病因素。

Correlation of precocious puberty and environmental endocrine disruptors

Objectives:To investigate the correlation of precocious puberty and environmental endocrine disruptors.Methods:115 girls with precocious puberty from February 2010 to February 2015 were selected as the observation group,and 115 healthy girls at the same time were selected as control group.All the girls received environmental endocrine disruptors and the uterine volume,bone density and serum levels of estradiol were detected to analyze analyze the correlation of precocious puberty and environmental endocrine disruptors.Results:The EEDs indicators DEHP,OP,BPA were significantly lower in the observation group than those in the control group,with significant difference (P ＜ 0.05).The uterine volume,ovarian volume,estradiol and bone density in the observation group were significantly higher than those in the control group,with significant difference (P ＜ 0.05).DEHP was positively correlated with uterine volume,ovarian volume and bone mineral density (P =0.001,0.003,O.000 respectively);OP and uterine volume was positively correlated (P =0.003);BPA and uterine volume and ovarian volume was positively correlated (P =0.000 and 0.042 respectively).Conclusion:The environmental endocrine disruptors is an important factor of precocious puberty.