舌下含服粉尘螨滴剂佐治儿童过敏性哮喘疗效观察

目的观察舌下含服粉尘螨滴剂佐治儿童过敏性哮喘的临床疗效。方法选取2012年1月至2014年5月湖南省儿童医院呼吸科就诊的过敏性哮喘患儿104例,随机分为观察组和对照组各52例。观察组患儿采用吸入性糖皮质激素联合舌下含服粉尘螨滴剂的治疗方法,对照组患儿采用联用吸入性糖皮质激素的治疗方法,比较两组患儿的治疗效果及用药安全性。结果治疗后观察组患儿哮喘发作次数及每次发作时长显著短于对照组,差异有统计学意义(P0.05)。治疗后观察组患儿肺功能评分显著高于对照组,粉尘螨皮肤点刺检测结果阴性率为94.2%(49/52),显著高于对照组80.7%(42/52),差异有统计学意义(P0.05)。治疗1年后,观察组哮喘控制率显著高于对照组,差异有统计学意义(P0.05)。观察组患儿出现用药不良反应2例,对照组3例,两组比较差异无统计学意义(P0.05)。结论舌下含服粉尘螨滴剂佐治儿童过敏性哮喘疗效显著。

Clinical observation on treatment effect on children with allergic asthma with sublingual drops

Objective To observe the clinical effect of sublingual Dermatophagoides Farinae drops on allergic asthma in children.Methods A total of 104 cases of children with allergic asthma who were treated from January 2012 to May 2014 in the Department of Respiration of Hunan Children's Hospital were selected, and were randomly divided into observation group and control group, with 52 cases in each group.The observation group was treated by inhaled corticosteroids combined with sublingual use of Dermatophagoides Farinae drops, while the control group were treated by inhaled corticosteroids.The therapeutic effect and safety of the two groups were compared.Results After the treatment, the frequency of asthma attacks and duration of each attack of observation group were significantly fewer and shorter than the control group, the difference being statistically significant(P<0.05).After treatment, the pulmonary function score of observation group was significantly higher than the control group.The dust mite skin prick test was negative in 94.2%(49/52) of the patients, significantly higher than the control group(80.7%, 42/52), and the difference was statistically significant(P<0.05).After 1 year of treatment, asthma control rate of the observation group was significantly higher than the control group, and the difference was statistically significant(P<0.05).Two patients in the observation group had adverse drug reaction, 3 in the control group, and there was no statistically significant difference between the groups(P>0.05).Conclusion The use of sublingual Dermatophagoides Farinae drops has significant curative effect on children with allergic asthma.