雌激素联合克罗米芬治疗多囊卵巢综合征效果研究

目的:探讨雌激素联合克罗米芬治疗多囊卵巢综合征患者的效果及对患者性生活状况的影响。方法:选择2015年7月至2016年7月在本院治疗的多囊卵巢综合征患者98例,随机分为观察组和对照组,各49例,对照组患者采用克罗米芬治疗,观察组在对照组的基础上联合小剂量雌激素,对比两组患者多毛、痤疮评分、性激素水平及性生活状态。结果:治疗后观察组患者多毛和痤疮评分分别为(4.94±2.73)分、(1.82±0.95)分,明显低于对照组患者;治疗后观察组患者睾酮、雌二醇、孕酮、促黄体生成素、促卵泡生成素水平分别为(1.28±0.30)nmol/L、(68.35±7.97)pmol/L、(13.36±2.07)m IU/m L、(8.24±1.23)m IU/m L,明显优于对照组患者;治疗后观察组患者性交干涩痛、性欲低下、性交频率下降比例分别为20.41%、26.53%、30.61%,明显低于对照组患者,差异具有统计学意义(P<0.05)。结论:雌激素联合克罗米芬有助于改善患者性激素水平、改善患者性生活质量,促进患者临床症状缓解。

Effect of estrogen and clomiphene for patients with polycystic ovary syndrome and their sexual life

Objectives:To investigate the effect of estrogen and clomiphene on patients with polycystic ovary syndrome (PCOS) and their sexual life.Methods:98 patients with PCOS treated in our hospital from July 2015 to July 2016 were randomly divided into observation group and control group,each of 49 cases.The control group was treated with clomiphene treatment,and on such basis observation group received additionally small dose of estrogen.The hirsutism,acne score,sex hormone level and sexual life status of the two groups were compared.Results:After treatment,the hirsutism and acne scores of patients in observation group were 4.94 ± 2.73 and 1.82 ± 0.95,significantly lower than those of the control group.The testosterone and estradiol,progesterone,LH,FSH levels in the observation group were (1.28 ± 0.30) nmol/L、(68.35 ± 7.97) pmol/L、(13.36 ± 2.07) mIU/mL、(8.24 ± 1.23) mIU/mL after treatment,obviously better than those in the control group.After treatment,the incidence of pain during sexual intercourse,low sexual desire and low frequency of sexual intercourse was respectively 20.41％,26.53 ％,30.61％,significantly lower than those of the control group,with statistically significant difference,P ＜ 0.05.Conclusion:Estrogen and clomiphene is conducive to improving the sex hormone levels and quality of sex life of patients.