山东省女性HPV6/11和HPV16/18感染情况分析

目的:对山东省女性人乳头状瘤病毒(human papillomavirus,HPV)6/11和HPV16/18感染的检测结果进行回顾分析,以了解山东省各年龄段、各地区女性HPV的感染状况。方法:采用实时荧光定量PCR技术,对2012年1月至2016年6月间济南金域医学检验中心收集的3995例和7508例样本,分别进行HPV6/11或HPV16/18检测,并对检测结果进行回顾分析。结果:HPV6/11检测的阳性率为27.2%(1085/3995),明显高于HPV16/18检测的5.1%(384/7508)。两种HPV检测的阳性率呈现不对称双峰分布,均以20岁组阳性率最高,分别为35.5%和21.7%。随后HPV6/11和HPV16/18的阳性率随年龄增长而逐渐下降,后HPV6/11的阳性率又逐渐升高至51~60岁组的34.3%和60岁组的43.8%;HPV16/18检测的阳性率在60岁组也略有上升,为3.4%。各地区中鲁中(31.6%)和鲁西(30.6%)HPV6/11的阳性率要高于鲁东(22.1%)和鲁北(21.7%);HPV16/18的检出率以鲁中(16.3%)最高,而鲁东最低(4.1%)。结论:本研究结果反映了山东省女性HPV6/11、HPV16/18感染的最新分布状况,对掌握山东省女性HPV感染的流行病学特征,为子宫颈癌筛查和HPV疫苗的接种提供科学依据。

Prevalence of human papillomavirus 6/11 and 16/18 among women in Shandong Province

Objectives:To investigate the prevalence of human papillomavirus (HPV) 6/11 and 16/18 among women at different ages and in different regions in Shandong Province.Methods:The 3,995 and 7,508 samples collected were by Jinan KingMed Diagnostics Center from January 2012 to June 2016 were tested for HPV 6/11 and 16/18 with real-time fluorescence quantitative PCR technology respectively.The overall prevalence,age-specific prevalence and region-specific prevalence were documented and analyzed.Results:The prevalence of HPV 6/11 (1085 cases,27.2％) was much higher than that of HPV 16/18 (384cases,5.1％).Age-specific prevalence showed an asymmetrical ‘two-peak’ pattern for both HPV 6/11 testing and 16/18 testing,with ＜ 20 years old group (35.5％ for HPV 6/11 and 21.7％ for HPV 16/18) presenting the highest HPV-positive rates.The prevalence of both HPV testing gradually declined with age,followed by a second peak in 51 ～ 60 years old group (34.3％) and ＞ 60 years old group (43.8％) for HPV 6/11 testing,and in ＞ 60 years old group (3.4％) for 16/18 testing,respectively.The positive rates of HPV 6/11 in central area (31.6％) and west area (30.6％) were much higher than those in other areas,while the positive rates of HPV 16/18 were highest in central area (16.3％) and lowest in east area (4.1％).Conclusion:The present study demonstrates that the prevalence of HPV 6/11 and 16/18 vary significantly among different ages and regions in Shandong Province,which represents the most cmrent survey of the prevalence of HPV 6/11 and 16/18,and can serve as valuable reference to guide cervical cancer screening and HPV vaccination programs.