解脲支原体感染对男女不育不孕的临床影响研究

目的:研究解脲支原体感染对男女不育不孕的影响,为临床提供依据。方法:选取2014年2月至2016年5月医院诊治的457例女性不孕症患者及其配偶457名为观察组,选取353名有正常生育史的育龄妇女及其353名配偶为对照组,采用PCR方法检测两组生殖道标本中解脲支原体感染情况,记录统计女性临床表现,采用CASA计算机辅助系统分析入选男性精子活力。结果:观察组女性解脲支原体感染检测阳性率为50.0%,男性解脲支原体感染检测阳性率为48.3%,显著高于对照组的15.6%及13.5%(P0.05);观察组男性向前运动精子、总活力及精子存活率,显著低于对照组(P0.05);观察组女性阴道分泌物增加、腹痛及腰骶痛例数,显著高于对照组(P0.05)。结论:解脲支原体对男、女不育不孕等均有明显的影响,应加强解脲支原体病原菌及药物试验,选择敏感抗生素,降低不孕不育率。

Clinical effects of ureaplasma urealyticum infection on male and female infertility

Objectives:To study the effect of ureaplasma urealyticum (UU) infection on male and female infertility,in order to provide the basis for clinical practice.Methods:457 female infertility patients and their spouses in our hospital from February 2014 to May 2016 were selected as observation group,and 353 women of childbearing age with a normal reproductive history and their spouses were selected as the control group.The UU infection situation of the two groups was detected by PCR;female clinical manifestations were recorded;and computer -aided CASA was used to analyze the sperm motility.Results:The female and male positive rate of UU infection in the observation group was 50.0％ and 48.3％ respectively,significantly higher than the 15.6％ and 13.5％ in the control group (P ＜ 0.05).The sperm forward motility,total viability and survival rate in the observation group was significantly lower than the control group (P ＜ 0.05).The number of female with increased vaginal secretions and abdominal pain and lumbosacral pain was significantly higher in the observation group than that in the control group (P ＜ 0.05).Conclusion:UU infection exerts a significant impact on both male and female infertility.Therefore,UU pathogens and drug test should be strengthened to select sensitive antibiotics to reduce the rate of infertility.