贲门黏膜癌前病变与胃不同位点Hp感染关系的研究

目的研究胃不同位点幽门螺旋杆菌感染与贲门黏膜癌前病变发生的关系。方法以我国上消化道肿瘤高发区江苏省扬中市上消化道内镜普查中2531例Hp阳性的当地居民为研究对象，在胃的不同位点（幽门前区0、6、9、3点方向各一块分别命名为Hp1、Hp2、Hp3、Hp4，胃角、胃小弯、胃底大弯、贲门嵴根各一块分别命名为Hp5、Hp6、Hp7、Hp8）取活检，活检组织经HE染色进行病理诊断，Giemsa染色找Hp。结果Hp7阳性人群贲门黏膜癌前病变的发生率为8．35％，显著高于Hp7阴性人群的发生率（x2=5．31，P〈0．05）；单一Hp7阳性人群贲门黏膜癌前病变的发生率为56．25％，渺著高于非单一Hp7阳性人群的发生率（x2=52．37，P〈0．05）；其他位点Hp阳性人群贲门黏膜癌前病变的发生曩墨显著低于阴性人群（P〈0．05）。结论贲门嵴根部位黏膜癌前期病变与胃底大弯Hp感染呈正相关，与其他部位的Hp感染呈负相关，根除Hp感染治疗有助于降低贲门癌发生的风险。

Relationship between precancerous lesions of gastric cardia and Hp infection in different sites of stomach

Objective To study relationship between the different sites of gastric helicobacter pylori infection and precancerous lesions in the cardia mucosa. Methods By objecting 2531 patients with Hp positive of local residents in Jiangsu pruvince Yangzhong city.The different sites in the stomach（pyloric region 0,6,9,3-point direction,respectively named Hpl,Hp2,Hp3,Hp4,gastric angle,lesser curvature,greater curvature,the root of gastric cardia ridge,respectively named Hp5,Hp6,Hp7,Hp8）biopsied,palhological diagnosised by HE staining,Giemsa staining to find Hp. Results Hp7 positive population Mallory incidence of precancerous lesions was 8.35%,significantly higher than the incidence of Hp7 negative population（x2=5.31, P 〈 0.05）;Single-positive of Hp7 incidence of precancerous lesions was 56.25%,significantly higher than the incidence of Hp7 non-single-positive population（x2=52.37,P 〈 0.05）;The incidence of other sites Hp-positive population precancerous lesions was significantly lower than negative population（P 〈 0.05）. Conclusion The cardia precancerous lesions was positively correlated with Hp infection in the greater curvature of gastric,and other parts of Hp infection was negatively correlated. Eradication of Hp can help reduce the risk of cardia cancer.