胰岛素泵持续皮下输注与多次皮下注射胰岛素强化治疗2型糖尿病的疗效比较

目的观察胰岛素泵持续皮下注射胰岛素及多次皮下注射胰岛素对2型糖尿病的治疗疗效及安全性。方法80例2型糖尿患者住院进行两种胰岛素强化治疗：①CSII组：42例；②MSII组：38例。二组治疗血糖控制范刖为3．6～8．2mm01／L（血糖仪测定末梢血），至少稳定48h。结果两种治疗方法血糖中位数差异有统计学意义（CSII：7．0，MSII：7．8，P〈0．01），平均高血糖控制天数CSII：（5．71±1．71）d，MSII：（20．52±7．68）d，P〈0．01]，胰岛素用量CSII（0．61±0．2）U／（kg·d），MSII：（0．69±0．2）U／（kg·d），P〈O．01]，住院时间CSII：（12．47±4．42）d，MSII：（31．43±9．47）d，P〈0．01]均有显著性差异；而住院费用CSII：（2787±1475）元，MSII：（3756±2867）元，P〈0．05]有统计学意义，且CSII组低糖发生率低于MSII组（0．8±1．2）次／，人VS（1．7±2．3）次／人，P〈0．051。结论CSll治疗较MSII更有效、更便捷地控制高血糖，减少低血糖发生，安全性更高。

Effect of continuous subcutaneous infusion with insulin pump on type 2 diabetes

Objective To observe the effects of tow different ways of insulin delivery and the security on type 2 diabetes patiellts. Methods Eighty poorly controlled type 2 diabetes were studied by 2 ways of intensive insulin delivery ： forty two cases were treated by continuous subcutaneous insulin infusion（CSII group）,while thirty eight cases by multiple subcutaneous insulin injection（MSll group）. The target BGs for both groups were premed ales and 2 hour post meals BGs ≥ 3.6 mmol/L ≤ 8.2mmol/L for at least forty eighl hours. Results Median of premeal BG was 7.0mmol/L in CSII ,was 7.8mmol/L in MSII（P 〈 0.01）. The average durations of treatmcnl CSII ： （5.71 ± 1.71） d, MSII： （20.52 ±7.68） d, P 〈 0.01] and insulin dosesCSII： （0.61±0.2）U/（kg · d）, MSII： （0.69 ± 0.2）U/（kg · d）, P 〈 0.01 land the duration of hospitalization CSII： （12.47 ±4.42）d, MSII： （31.43 ±9.47）d, P 〈 0.01] were significantly different.The hospitalization expenses CSII： （2787 ± 1475）yuan, MSII： （3757 ± 2867）yuan, P 〈 0.05] had statistics significance. The hypoglycemia incidence in CSII was（0.8± 1.2）time/case, in MSII： （1.7±2.3）time/case（P 〈 0.05）. Conclusion Compared with multiple subcutaneous insulin injection, continuous subcutaneous infusion with insulin pump could coutrol the hyperglycemia more effectively, more rapidly and reduce the hypoglycemia risk in treatmeat of type 2 diabetes.The forward way is more security to the after.