78例NSCLC血清VEGF表达临床意义分析

目的检测非小细胞肺癌患者化疗前外周血血管内皮生长因子的水平，探讨其与化疗疗效、预后的关系。方法鹪联免疫吸附试验检测78例NSCLC患者化疗前血清VEGF水平，并采用x2检验、Kaplan—Meier生存曲线比较与VEGF表达相关因素及其对生存期的影响。结果在NSCLC中，血清VEGF阳性率为30．8％（24／78）。VEGF的表达与淋出结转移、远处转移、TNM分期、化疗疗效密切相关，但与年龄、性别、病理类型等无关。VEGF阳性组的生存期与阴性绀相比接近统计学意义（P=0．0741）。结论检测NSCLC患者外周血VEGF，可能有利于协助预测转移、评价化疗疗效及判断预后。

Clinical significance of serum VEGF in 78 patients with non-small cell lung cancer

Objective To measure serum levels of VEGF in non-small cell lung cancer（NSCLC）patients and evaluate their prognoslic value. Methods The serum levels of VEGF,in 78 cases with NSCLC were measured by ELISA before chemotherapy.Expression differences of VEGF and its relationship with the patients＇survival were analyzed with x2 test,Kaplan-Meier survival curve. Results VEGF expression were found in 24 cases （30.8%）. The serum levels of VEGF in patients before chemotherapy were significantly correlated to the lymph node metastasis,the distant metastasis,the TNM stage and the curative effect. No correlation was found among the expression of VEGF and the following clinical parameters such as age, sex, histological subtype. The differnnces of survival time between VEGF positive and negative expression NSCLC patients were approximate significant（P=0.074 1）. Conclusion The measurement of serum levels of VEGF in advanced NSCLC is helpful for prediction of metastasis tendency and evaluation of prognosis.